Fleckman P, Olerud J E
Division of Dermatology, University of Washington School of Medicine, Seattle, WA 98195-6524, USA.
Biomed Mater. 2008 Sep;3(3):034006. doi: 10.1088/1748-6041/3/3/034006. Epub 2008 Aug 15.
Percutaneous devices are critical for health care. Access to tissue, vessels and internal organs afforded by these devices provides the means to treat and monitor many diseases. Unfortunately, such access is not restricted, and infection may compromise the usefulness of the device and even the life of the patient. New biomaterials offer the possibility of maintaining internal access while limiting microbial access, but understanding of the cutaneous/biomaterial interface and models to study this area are limited. This paper focuses on models useful for studying the morphology and biology of the intersection of skin and percutaneous biomaterials. An organ culture and a mouse model are described that offer promising possibilities for improved understanding of this critical interface.
经皮设备对医疗保健至关重要。这些设备提供的进入组织、血管和内部器官的途径为治疗和监测多种疾病提供了手段。不幸的是，这种进入途径不受限制，感染可能会损害设备的效用，甚至危及患者生命。新型生物材料提供了在限制微生物进入的同时维持内部通路的可能性，但对皮肤/生物材料界面的理解以及用于研究该领域的模型有限。本文重点关注有助于研究皮肤与经皮生物材料交叉部位的形态学和生物学的模型。描述了一种器官培养模型和一种小鼠模型，它们为更好地理解这一关键界面提供了有前景的可能性。
