Hegyi Juraj, Frey Tomas, Arenberger Petr
Department of Dermatovenerology, 3rd Medical Faculty, Charles University, Prague, Czech Republic.
Acta Dermatovenerol Alp Pannonica Adriat. 2008 Jun;17(2):75-8.
Mycosis fungoides, or cutaneous T-cell lymphoma (CTCL), is one of the most common skin lymphomas, with a chronic and lethal course. It is characterized by the expansion of CD4+ and CDw29+ immunophenotype T-cell clones lacking normal antigens. These altered T-lymphocytes are predominantly located in the skin, but some of them retain their ability to migrate and exit the skin through the lymphatics into the circulatory system.
We report on a 78-year-old man with an 8-year history of histologically verified Mycosis fungoides. Twenty-five years ago, the patient was incorrectly diagnosed with psoriasis vulgaris and received therapy with only slight effect. In 1999 the patient underwent full body actinotherapy (30 Gy) which resulted in complete remission of CTCL lesions on the skin. In October 2005 the patient presented at our department with a new partially infiltrated lesion 14x6 cm in his right groin. Because photochemotherapy and local therapy with corticosteroids had already been used without significant results, we opted for photodynamic therapy (PDT) with methyl aminolevulinate (MAL).
蕈样肉芽肿，即皮肤T细胞淋巴瘤（CTCL），是最常见的皮肤淋巴瘤之一，病程呈慢性且具有致命性。其特征为缺乏正常抗原的CD4+和CDw29+免疫表型T细胞克隆的扩增。这些改变的T淋巴细胞主要位于皮肤，但其中一些仍保留通过淋巴管迁移并离开皮肤进入循环系统的能力。
我们报告一例78岁男性，有8年经组织学证实的蕈样肉芽肿病史。25年前，该患者被误诊为寻常型银屑病，接受治疗后效果甚微。1999年，患者接受全身放线疗法（30 Gy），皮肤CTCL病变完全缓解。2005年10月，该患者因右腹股沟出现一个新的14×6 cm部分浸润性病变前来我院就诊。由于光化学疗法和局部使用皮质类固醇均未见明显效果，我们选择使用甲基氨基酮戊酸（MAL）进行光动力疗法（PDT）。
