Skiveren Jette, Kjaerby Emmy, Nordahl Larsen Heidi
Department of Dermatology, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen, Denmark.
Acta Derm Venereol. 2008;88(4):366-9. doi: 10.2340/00015555-0465.
Botulinum toxin A injection is a well-described efficacious treatment for axillary hyperhidrosis. Although considered a safe treatment, many patients experience pain during injections. The purpose of the present study was to examine whether cooling by frozen gel packs applied in the axilla for 5 min before treatment could reduce pain. Thirty-six patients with axillary hyperhidrosis were included in this randomized, open-label prospective study, in which patients were their own controls. Pain was assessed before, during (four times), and immediately after treatment, using a numeric rating scale. The patients experienced statistically significant pain reduction, of 14-19%, in areas cooled by frozen gel pack (p<0.01). However, the clinical relevance of this relatively small pain reduction is questionable.
肉毒杆菌毒素A注射是一种已被充分描述的治疗腋窝多汗症的有效方法。尽管被认为是一种安全的治疗方法，但许多患者在注射过程中会感到疼痛。本研究的目的是检查在治疗前在腋窝应用冷冻凝胶袋冷却5分钟是否可以减轻疼痛。36例腋窝多汗症患者纳入了这项随机、开放标签的前瞻性研究，其中患者自身作为对照。使用数字评分量表在治疗前、治疗期间（四次）和治疗后立即评估疼痛。在使用冷冻凝胶袋冷却的区域，患者经历了具有统计学意义的疼痛减轻，减轻幅度为14%-19%（p<0.01）。然而，这种相对较小的疼痛减轻的临床相关性值得怀疑。
