Department of Urology and Andrology, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.
Int J Clin Oncol. 2010 Oct;15(5):472-5. doi: 10.1007/s10147-010-0095-0. Epub 2010 Jun 11.
Goserelin acetate, which is injected through a 16-gauge needle, makes some patients feel substantial, although tolerable, pain. We tried to clarify whether injection pain was reduced by icing the skin at the injection site.
Pain associated with the injection of goserelin acetate was prospectively evaluated in 48 patients who had received an 10.8-mg goserelin injection at least once previously. In this study, the first injection was administered by usual methods, and 3 months later a second injection was administered after icing the skin at the injection site. Pain intensity was evaluated by visual analogue scale (VAS) pain score.
VAS pain scores for the usual injection method were 32.4 ± 21.7 mm [mean ± 2 standard deviation (SD)] and was significantly lower (16.4 ± 17.9) for the icing method (p = 0.001, paired t test). Thirty-three (68.8%), eight (16.7%), and seven (14.6%) of the 48 patients reported a decrease, no change, and increase, respectively, in VAS pain score by the icing method.
Icing at the injection site of goserelin acetate is a safe and effective method to reduce injection pain. This method can be easily performed in daily practice if a patient complains of pain at the injection site.
醋酸戈舍瑞林通过 16 号针头注射，尽管可以耐受，但仍会让一些患者感到明显的疼痛。我们试图明确在注射部位冰敷是否可以减轻注射疼痛。
对 48 例至少接受过一次 10.8mg 戈舍瑞林注射的患者前瞻性评估了醋酸戈舍瑞林注射相关疼痛。在这项研究中，首次注射采用常规方法，3 个月后在注射部位冰敷后进行第二次注射。采用视觉模拟评分（VAS）评估疼痛强度。
常规注射方法的 VAS 疼痛评分为 32.4 ± 21.7mm（均值 ± 2 个标准差），冰敷方法的 VAS 疼痛评分明显较低（16.4 ± 17.9，p = 0.001，配对 t 检验）。48 例患者中，33 例（68.8%）、8 例（16.7%）和 7 例（14.6%）分别报告冰敷法的 VAS 疼痛评分降低、无变化和增加。
在醋酸戈舍瑞林注射部位冰敷是减轻注射疼痛的一种安全有效的方法。如果患者对注射部位疼痛有抱怨，这种方法可以在日常实践中轻松实施。
