Bertschinger Dimiter R, Beknazar Evgueny, Simonutti Manuel, Safran Avinoam B, Sahel José A, Rosolen Serge G, Picaud Serge, Salzmann Joel
Geneva University Eye Service, 22 rue Alcide Jentzer, 1211, Geneva 14, Switzerland.
Graefes Arch Clin Exp Ophthalmol. 2008 Nov;246(11):1505-17. doi: 10.1007/s00417-008-0891-7. Epub 2008 Aug 16.
The development of a functional retinal prosthesis for acquired blindness is a great challenge. Rapid progress in the field over the last 15 years would not have been possible without extensive animal experimentation pertaining to device design and fabrication, biocompatibility, stimulation parameters and functional responses. This paper presents an overview of in vivo animal research related to retinal prosthetics, and aims to summarize the relevant studies.
A Pubmed search of the English language literature was performed. The key search terms were: retinal implant, retinal prosthesis, artificial vision, rat, rabbit, cat, dog, sheep, pig, minipig. In addition a manual search was performed based on references quoted in the articles retrieved through Pubmed.
We identified 50 articles relevant to in vivo animal experimentation directly related to the development of a retinal implant. The highest number of publications related to the cat (n = 18).
The contribution of animal models to the development of retinal prosthetic devices has been enormous, and has led to human feasibility studies. Grey areas remain regarding long-term tissue-implant interactions, biomaterials, prosthesis design and neural adaptation. Animals will continue to play a key role in this rapidly evolving field.
开发用于后天性失明的功能性视网膜假体是一项巨大挑战。如果没有在设备设计与制造、生物相容性、刺激参数及功能反应等方面进行广泛的动物实验，过去15年该领域就不可能取得快速进展。本文概述了与视网膜假体相关的体内动物研究，并旨在总结相关研究。
在PubMed上搜索英文文献。关键搜索词为：视网膜植入物、视网膜假体、人工视觉、大鼠、兔子、猫、狗、绵羊、猪、小型猪。此外，还根据通过PubMed检索到的文章中引用的参考文献进行了手动搜索。
我们确定了50篇与视网膜植入物开发直接相关的体内动物实验相关文章。与猫相关的出版物数量最多（n = 18）。
动物模型对视网膜假体装置的开发贡献巨大，并已促成人体可行性研究。在长期组织 - 植入物相互作用、生物材料、假体设计和神经适应方面仍存在灰色地带。动物将继续在这个快速发展的领域中发挥关键作用。
