肝脏/脾脏体积比作为原发性胆汁性肝硬化预后的预测指标
Liver/spleen volume ratio as a predictor of prognosis in primary biliary cirrhosis.
作者信息
Murata Yosuke, Abe Masanori, Hiasa Yoichi, Azemoto Nobuaki, Kumagi Teru, Furukawa Shinya, Matsuura Bunzo, Michitaka Kojiro, Horiike Norio, Onji Morikazu
机构信息
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, 791-0295, Japan.
出版信息
J Gastroenterol. 2008;43(8):632-6. doi: 10.1007/s00535-008-2202-9. Epub 2008 Aug 17.
BACKGROUND
The course of primary biliary cirrhosis (PBC) is determined by clinical symptoms and histological findings. The present study examined the prognostic importance of imaging parameters in PBC.
METHODS
The volumes of the liver and spleen of patients with PBC were assessed by computed tomography (CT). The volume ratio of liver to spleen (LV/SV ratio) was evaluated and used for further analyses.
RESULTS
The prognosis was significantly poorer in PBC patients with a low, rather than high, LV/SV ratio. The Cox proportional hazard regression model showed that the serum bilirubin level and the LV/SV ratio could predict the prognosis of PBC patients. In addition, the LV/SV ratio was significantly lower in patients who developed symptoms (s-PBC) than in those who remained asymptomatic (a-PBC) during the observation period.
CONCLUSIONS
The LV/SV ratio is of prognostic importance in patients with PBC.
背景
原发性胆汁性肝硬化（PBC）的病程由临床症状和组织学检查结果决定。本研究探讨了影像学参数在PBC中的预后意义。
方法
采用计算机断层扫描（CT）评估PBC患者的肝脏和脾脏体积。评估肝脏与脾脏的体积比（LV/SV比）并用于进一步分析。
结果
LV/SV比低的PBC患者预后明显比LV/SV比高的患者差。Cox比例风险回归模型显示，血清胆红素水平和LV/SV比可预测PBC患者的预后。此外，在观察期内出现症状的患者（s-PBC）的LV/SV比显著低于无症状患者（a-PBC）。
结论
LV/SV比在PBC患者中具有预后意义。
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