Vauthey Jean-Nicolas, Abdalla Eddie K, Doherty Dorota A, Gertsch Philippe, Fenstermacher Marc J, Loyer Evelyne M, Lerut Jan, Materne Roland, Wang Xuemei, Encarnacion Arthur, Herron Delise, Mathey Christian, Ferrari Giovanni, Charnsangavej Chuslip, Do Kim-Anh, Denys Alban
Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Liver Transpl. 2002 Mar;8(3):233-40. doi: 10.1053/jlts.2002.31654.
Computed tomography (CT) is used increasingly to measure liver volume in patients undergoing evaluation for transplantation or resection. This study is designed to determine a formula predicting total liver volume (TLV) based on body surface area (BSA) or body weight in Western adults. TLV was measured in 292 patients from four Western centers. Liver volumes were calculated from helical computed tomographic scans obtained for conditions unrelated to the hepatobiliary system. BSA was calculated based on height and weight. Each center used a different established method of three-dimensional volume reconstruction. Using regression analysis, measurements were compared, and formulas correlating BSA or body weight to TLV were established. A linear regression formula to estimate TLV based on BSA was obtained: TLV = -794.41 + 1,267.28 x BSA (square meters; r(2) = 0.46; P <.0001). A formula based on patient weight also was derived: TLV = 191.80 + 18.51 x weight (kilograms; r(2) = 0.49; P <.0001). The newly derived TLV formula based on BSA was compared with previously reported formulas. The application of a formula obtained from healthy Japanese individuals underestimated TLV. Two formulas derived from autopsy data for Western populations were similar to the newly derived BSA formula, with a slight overestimation of TLV. In conclusion, hepatic three-dimensional volume reconstruction based on helical CT predicts TLV based on BSA or body weight. The new formulas derived from this correlation should contribute to the estimation of TLV before liver transplantation or major hepatic resection.
计算机断层扫描（CT）越来越多地用于对接受移植或肝切除评估的患者进行肝脏体积测量。本研究旨在确定基于西方成年人的体表面积（BSA）或体重预测全肝体积（TLV）的公式。对来自四个西方中心的292例患者进行了TLV测量。肝脏体积通过针对与肝胆系统无关的情况获得的螺旋计算机断层扫描进行计算。BSA根据身高和体重计算得出。每个中心都使用了不同的既定三维体积重建方法。通过回归分析比较测量结果，并建立将BSA或体重与TLV相关联的公式。获得了基于BSA估计TLV的线性回归公式：TLV = -794.41 + 1,267.28×BSA（平方米；r² = 0.46；P <.0001）。还得出了一个基于患者体重的公式：TLV = 191.80 + 18.51×体重（千克；r² = 0.49；P <.0001）。将新得出的基于BSA的TLV公式与先前报道的公式进行了比较。应用从健康日本个体获得的公式会低估TLV。从西方人群尸检数据得出的两个公式与新得出的基于BSA的公式相似，但对TLV有轻微高估。总之，基于螺旋CT的肝脏三维体积重建可根据BSA或体重预测TLV。基于这种相关性得出的新公式应有助于肝移植或重大肝切除术前TLV的估计。
