Kastin Abba J, Pan Weihong
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
Crit Rev Toxicol. 2008;38(7):629-31. doi: 10.1080/10408440802026372.
Biology is replete with examples of hormesis, the term introduced and developed by Calabrese. The corresponding concept in the field of peptide research has been characterized as the inverted U-shaped dose-response relationship. The articles by Calabrese in this issue summarize the notable progress occurring in the past three decades. In contrast to the skepticism encountered when we introduced this concept for peptides in the early 1970s, hormesis is now becoming recognized as characteristic of many actions of these small proteins. Calabrese is performing a considerable service by his strong advocacy and promotion of the concept to a more general readership. Hopefully, hormesis will be routinely considered in the design of research projects and the discovery of pharmaceutical agents.
生物学中充满了毒物兴奋效应的例子，这个术语是由卡拉布雷斯提出并发展的。肽研究领域中的相应概念已被描述为倒U形剂量反应关系。卡拉布雷斯在本期发表的文章总结了过去三十年中取得的显著进展。与我们在20世纪70年代初首次提出肽的这一概念时所遭遇的怀疑态度不同，如今毒物兴奋效应正逐渐被视作这些小蛋白质多种作用的特征。卡拉布雷斯大力倡导并向更广泛的读者群体推广这一概念，他做出了相当大的贡献。有望在研究项目设计和药物制剂发现过程中常规性地考虑毒物兴奋效应。
