Calabrese Edward J
Department of Public Health, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.
Ageing Res Rev. 2008 Jan;7(1):8-20. doi: 10.1016/j.arr.2007.07.001. Epub 2007 Jul 31.
The adaptive response in toxicology and environmental mutagenesis, preconditioning in biomedicine and the Yerkes-Dodson Law in psychology have dominating research themes with widespread and significant scientific and societal implications. This paper suggests that these apparently independent biological dose-response phenomena are manifestations of the common and more general biphasic dose-response relationship concept called hormesis. These three types of dose-response, as well as the hormesis concept, may represent the same general type of adaptation, which were discovered independently in different biological disciplines, amongst which there has been little communication. This intellectual isolation, due principally to progressively greater disciplinary specialization, resulted in the evolution of different terminologies for dose-response phenomena with strikingly similar quantitative features. This lack of recognition of converging dose-response concepts across disciplines has important implications since it limits the recognition of a common and basic biological concept while minimizing collaborations by investigators in related areas. The paper concludes that the broadly recognized biological adaptive responses, as described by the concepts of adaptive response, preconditioning and the Yerkes-Dodson Law, are special cases of the more general hormesis dose-response concept.
毒理学和环境诱变中的适应性反应、生物医学中的预处理以及心理学中的耶基斯 - 多德森定律，这些研究主题具有广泛且重大的科学和社会意义。本文指出，这些看似独立的生物剂量反应现象是一种被称为兴奋效应的常见且更普遍的双相剂量反应关系概念的表现形式。这三种类型的剂量反应以及兴奋效应概念，可能代表了同一类普遍的适应类型，它们在不同的生物学学科中被独立发现，而这些学科之间几乎没有交流。这种知识上的孤立主要是由于学科专业化程度日益提高，导致对具有惊人相似定量特征的剂量反应现象出现了不同的术语。跨学科对趋同剂量反应概念的这种缺乏认识具有重要影响，因为它限制了对一个共同且基本的生物学概念的认识，同时减少了相关领域研究人员之间的合作。本文的结论是，适应性反应、预处理和耶基斯 - 多德森定律等被广泛认可的生物适应性反应，是更普遍的兴奋效应剂量反应概念的特殊情况。
