Eisner Alvin, Thielman Emily J, Falardeau Julie, Vetto John T
Casey Eye Institute, Oregon Health & Science University, Portland, USA.
Breast Cancer Res Treat. 2009 Sep;117(1):9-16. doi: 10.1007/s10549-008-0156-5. Epub 2008 Aug 20.
This study tested a prediction stemming from the hypothesis that anastrozole users experience heightened vitreo-retinal traction. This hypothesis was based on the knowledge that menopause increases the risk of intraocular tractional events such as posterior vitreous detachments (PVDs).
Retinal thickness was measured for 3 groups of amenorrheic women: (1) anastrozole users and (2) tamoxifen users undergoing adjuvant therapy for early-stage breast cancer, and (3) control subjects not using hormonal medication. Foveal shape indices were derived for subjects without PVDs.
For anastrozole users, the distance to the temporal side of the fovea became less than the distance to the nasal side at a sufficient height above the foveal base. This effect did not exist for control subjects; the between-group difference was appreciable. Results concerning tamoxifen users were inconclusive.
The foveas of women using anastrozole appear to be subjected to more tractional force than are the foveas of women not using any hormonal medication.
本研究验证了源自以下假设的一项预测，即使用阿那曲唑的患者会经历增强的玻璃体视网膜牵拉。该假设基于以下认识：绝经会增加眼内牵拉性事件的风险，如玻璃体后脱离（PVD）。
对3组闭经女性测量视网膜厚度：（1）使用阿那曲唑的患者；（2）接受早期乳腺癌辅助治疗的使用他莫昔芬的患者；（3）未使用激素药物的对照受试者。为无PVD的受试者得出黄斑形状指数。
对于使用阿那曲唑的患者，在黄斑基部上方足够高度处，黄斑颞侧的距离变得小于黄斑鼻侧的距离。对照受试者不存在这种效应；组间差异明显。关于使用他莫昔芬的患者的结果尚无定论。
使用阿那曲唑的女性的黄斑似乎比未使用任何激素药物的女性的黄斑承受更大的牵拉力。
