Deniz Kemal, Yüce Imdat, Cağli Sedat, Okten Turhan, Güney Ercihan
Department of Pathology, Erciyes University Faculty of Medicine, 38039 Kayseri, Turkey.
Ear Nose Throat J. 2008 Aug;87(8):469-73.
We investigated the difference in the biologic nature of typical squamous cell carcinoma (SCC) and basaloid SCC (BSCC) of the larynx by studying proliferation and antiapoptotic markers. We performed an immunohistochemical analysis of the expression of proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 15 patients with laryngeal BSCC and 15 stage- and site-matched controls with typical laryngeal SCC. We found no significant difference between the two groups in the PCNA index or the frequency of bcl-2 overexpression, nor did we find any significant difference in survival. Our findings indicate that the biologic nature of typical laryngeal SCC and laryngeal BSCC is similar. In addition, our follow-up data suggest that the clinical course of laryngeal BSCC is no worse than that of typical laryngeal SCC.
我们通过研究增殖和抗凋亡标志物，调查了喉典型鳞状细胞癌（SCC）和基底样鳞状细胞癌（BSCC）生物学特性的差异。我们对15例喉BSCC患者以及15例分期和部位匹配的喉典型SCC对照患者的增殖细胞核抗原（PCNA）和bcl-2蛋白表达进行了免疫组化分析。我们发现两组在PCNA指数或bcl-2过表达频率方面无显著差异，在生存率方面也未发现任何显著差异。我们的研究结果表明，喉典型SCC和喉BSCC的生物学特性相似。此外，我们的随访数据表明，喉BSCC的临床病程并不比喉典型SCC差。
