Reimer P, Weissleder R, Brady T J, Yeager A E, Baldwin B H, Tennant B C, Wittenberg J
MGH-NMR Center, Charlestown, MA 02129.
Radiology. 1991 Sep;180(3):641-5. doi: 10.1148/radiology.180.3.1871273.
Relaxation time measurements and magnetic resonance (MR) imaging were performed in three different animal models of hepatocellular carcinoma (HCC). After intravenous administration of asialoglycoprotein-directed arabinogalactan-stabilized ultrasmall superparamagnetic iron oxide (10 mumol Fe/kg receptor agent), T2 of normal liver decreased from 41.6 msec +/- 1.0 to 19.4 msec +/- 1.7 (P less than .05) in rats. T2 of HCC implanted in normal liver or liver with chronic hepatitis was essentially unchanged. These results were similar to those obtained by administration of a reticuloendothelial cell-directed conventional iron oxide; however, the required dose of receptor agent was lower. MR imaging in a woodchuck model of virally induced HCC confirmed the distribution of the hepatocyte-directed agent to regions of functioning and differentiated hepatocytes but not to malignant tumor tissue. The results suggest that MR receptor imaging may play a role in the differentiation between primary liver tumor and functional liver tissue such as that in normal liver hepatitis or regenerating nodules.
在三种不同的肝细胞癌（HCC）动物模型中进行了弛豫时间测量和磁共振（MR）成像。静脉注射去唾液酸糖蛋白导向的阿拉伯半乳聚糖稳定的超小超顺磁性氧化铁（10 μmol Fe/kg受体剂）后，大鼠正常肝脏的T2从41.6毫秒±1.0降至19.4毫秒±1.7（P<0.05）。植入正常肝脏或慢性肝炎肝脏中的HCC的T2基本未变。这些结果与通过给予网状内皮细胞导向的传统氧化铁获得的结果相似；然而，受体剂所需剂量更低。在病毒诱导的HCC土拨鼠模型中的MR成像证实了肝细胞导向剂在功能正常和分化的肝细胞区域的分布，但在恶性肿瘤组织中未分布。结果表明，MR受体成像可能在原发性肝肿瘤与正常肝脏、肝炎或再生结节等功能性肝组织之间的鉴别中发挥作用。
