Mushtaq Sajid, Akhtar Nooren, Jamal Shahid, Mamoon Nadira, Khadim Tahir, Sarfaraz Tariq, Waqar Amin
Army Medical College, Rawalpindi, Pakistan.
Asian Pac J Cancer Prev. 2008 Apr-Jun;9(2):229-32.
To determine the spectrum of malignant lymphomas in our set up, according to the WHO classification.
All the cases diagnosed as malignant lymphoma, during the year 2005, were retrieved from the institution based tumour registry record and classified according to WHO criteria depending on the immunohistochemical results of a panel of lymphoma markers.
The male to female ratio was 2.5:1 for almost all types of malignant lymphomas. The age range was 3 to 80 years. The frequency of Hodgkin's lymphoma, Burkitt's lymphoma and lymphoblastic lymphoma were higher amongst the children, whereas follicular lymphomas, mantle cell lymphoma and CLL/SLL were more frequently reported in 5th, 6th and 7th decades. Of the total cases 62% were nodal and 38% extranodal (majority in the GI tract). Non Hodgkin's lymphoma was more (73%) frequent than Hodgkin's disease. Mixed cellularity and nodular sclerosis were the main histological variants of Hodgkin's disease.
Immunohistochemistry is not very frequently used in our set up and also at very few other centres. Therefore, its application should be encouraged to raise the quality of data on lymphoid neoplasms and contribute to their control.
根据世界卫生组织（WHO）分类，确定我们所研究病例中恶性淋巴瘤的谱型。
从机构肿瘤登记记录中检索出2005年期间所有诊断为恶性淋巴瘤的病例，并根据一组淋巴瘤标志物的免疫组化结果，按照WHO标准进行分类。
几乎所有类型的恶性淋巴瘤男女比例均为2.5:1。年龄范围为3至80岁。霍奇金淋巴瘤、伯基特淋巴瘤和淋巴母细胞淋巴瘤在儿童中更为常见，而滤泡性淋巴瘤、套细胞淋巴瘤和慢性淋巴细胞白血病/小淋巴细胞淋巴瘤在五、六、七十岁人群中报告更为频繁。在所有病例中，62%为淋巴结受累，38%为结外受累（多数在胃肠道）。非霍奇金淋巴瘤（73%）比霍奇金病更为常见。混合细胞型和结节硬化型是霍奇金病的主要组织学亚型。
免疫组化在我们的研究机构以及其他极少中心使用并不频繁。因此，应鼓励应用免疫组化以提高淋巴肿瘤数据质量并有助于对其进行控制。
