Sultan Sadia, Baloch Naseer, Ahmed Zeeshan Ansar, Irfan Syed Mohammed, Parveen Saira
Department of Hematology and Blood Bank, Liaquat National Hospital and Medical College, Karachi, Pakistan.
Department of Anatomy, Liaquat National Medical College, Karachi, Pakistan.
J Lab Physicians. 2018 Jan-Mar;10(1):17-20. doi: 10.4103/JLP.JLP_9_17.
Limited information is available from developing countries in patients of non-Hodgkin's lymphoma (NHL). Hence, we reviewed the demographical profile along with bone marrow infiltration pattern in patients with NHL presented at Liaquat National Hospital and Medical College.
In this descriptive study, adult patients with NHL were enrolled from January 2011 to December 2015.
One hundred and Eighty-four histopathologically confirmed cases of NHL were identified. There were 139 males and 45 females, with a male-to-female ratio of 3:1. The mean age was 48.5 ± 16.0 years with the median age of 50 years. B-symptoms were present in 80.4% of patients. Lymph node enlargement was present in 71.1% of the cases. One hundred and sixty-eight patients had B-cell lymphoma (91.3%) and 16 patients had T-cell lymphoma (8.6%). Overall 158 (85.8%) patients had aggressive lymphoma. The frequency of bone marrow infiltration in our NHL patients was found to be 31.5%. Pattern of infiltrate was diffuse (14.6%) predominantly followed by interstitial (6.5%) and paratrabecular (5.4%) types of infiltration. The least common was nodular infiltrate accounted in 9 (4.8%) patients.
B-cell lymphoma is more frequent than T-cell lymphoma. Younger age, aggressive lymphoma, and predominance of B-symptoms are more frequently seen. Diffuse bone marrow infiltration is more common in our set up probably because of a relatively late presentation in our patients.
来自发展中国家的非霍奇金淋巴瘤（NHL）患者的信息有限。因此，我们回顾了在利亚卡特国家医院和医学院就诊的NHL患者的人口统计学特征以及骨髓浸润模式。
在这项描述性研究中，纳入了2011年1月至2015年12月期间的成年NHL患者。
共确定了184例经组织病理学确诊的NHL病例。其中男性139例，女性45例，男女比例为3:1。平均年龄为48.5±16.0岁，中位年龄为50岁。80.4%的患者有B症状。71.1%的病例有淋巴结肿大。168例患者为B细胞淋巴瘤（91.3%），16例患者为T细胞淋巴瘤（8.6%）。总体而言，158例（85.8%）患者患有侵袭性淋巴瘤。我们的NHL患者中骨髓浸润的发生率为31.5%。浸润模式以弥漫性（14.6%）为主，其次是间质型（6.5%）和小梁旁型（5.4%）。最不常见的是结节性浸润，有9例（4.8%）患者。
B细胞淋巴瘤比T细胞淋巴瘤更常见。患者更常表现为较年轻的年龄、侵袭性淋巴瘤以及B症状占主导。在我们的研究中，弥漫性骨髓浸润更为常见，这可能是因为我们的患者就诊相对较晚。
