Wolf Oliver T, Kudielka Brigitte M
Department of Cognitive Psychology, Ruhr-University Bochum, Universitätsstrasse 150, D-44780 Bochum, Germany.
Menopause Int. 2008 Sep;14(3):129-33. doi: 10.1258/mi.2008.008021.
Stress influences health and disease and this might be of special relevance for ageing. The present review starts with the description of age-associated changes of the hypothalamic-pituitary-adrenal axis. In this context, the possible modulatory role of estradiol is discussed. Later, the influence of rising stress hormone levels for the ageing brain is illustrated and a few intervention strategies are outlined. At the end, the concept of allostatic load (AL) is described, which aims at a broader assessment of the impact of stress on the individual. The strengths and also the current limitations of the AL concept are highlighted.
压力会影响健康和疾病，这可能与衰老尤其相关。本综述首先描述下丘脑-垂体-肾上腺轴的年龄相关变化。在此背景下，讨论了雌二醇可能的调节作用。随后，阐述了应激激素水平升高对衰老大脑的影响，并概述了一些干预策略。最后，描述了应激负荷（AL）的概念，其旨在更广泛地评估压力对个体的影响。强调了AL概念的优势以及当前的局限性。
