Clark Mary J, Schopp Laura H, Mazurek Micah O, Zaniletti Isabella, Lammy Andrew B, Martin Thomas A, Thomas Florian P, Acuff Michael E
Department of Health Psychology, University of Missouri, Columbia, Missouri, USA.
Am J Phys Med Rehabil. 2008 Sep;87(9):758-67. doi: 10.1097/PHM.0b013e3181837f4f.
The objectives of the present study were to determine the prevalence of low testosterone among a sample of men with spinal cord injury and to examine the relationship among testosterone, time since injury, and select laboratory values.
Participants were 102 men with spinal cord injury participating in inpatient or outpatient rehabilitation. Data included total serum testosterone level, demographic and injury information, and laboratory values.
Sixty percent of men with spinal cord injury had low testosterone levels. The median testosterone level for the entire sample was 220 ng/dl (normal reference range = 241-827 ng/dl). Low testosterone was significantly associated with less time since injury, lower hemoglobin, and higher prolactin in the univariate analyses at P < 0.05.
The results indicate that men with spinal cord injury are at risk for low serum testosterone. Testosterone levels were also related to time since injury and hemoglobin and prolactin levels. These findings suggest the need for changes to occur in clinical practice. Guidelines are needed for when and how often testosterone monitoring should be conducted. Future research should address the pathophysiology of low testosterone and the outcomes of testosterone treatment.
本研究的目的是确定脊髓损伤男性样本中低睾酮的患病率，并研究睾酮、受伤时间和选定实验室指标之间的关系。
102名参与住院或门诊康复的脊髓损伤男性为研究对象。数据包括血清总睾酮水平、人口统计学和损伤信息以及实验室指标。
60%的脊髓损伤男性睾酮水平较低。整个样本的睾酮水平中位数为220 ng/dl（正常参考范围=241-827 ng/dl）。在单因素分析中，低睾酮与受伤时间较短、血红蛋白水平较低和催乳素水平较高显著相关（P<0.05）。
结果表明脊髓损伤男性存在血清睾酮水平低的风险。睾酮水平还与受伤时间、血红蛋白和催乳素水平有关。这些发现表明临床实践需要做出改变。需要制定关于何时以及多久进行一次睾酮监测的指南。未来的研究应探讨低睾酮的病理生理学以及睾酮治疗的效果。
