在禽流感病毒基因背景下携带马1型（H7N7）流感病毒血凝素的重配病毒对鸡具有致病性。
Reassortants with equine 1 (H7N7) influenza virus hemagglutinin in an avian influenza virus genetic background are pathogenic in chickens.
作者信息
Banbura M W, Kawaoka Y, Thomas T L, Webster R G
机构信息
Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
出版信息
Virology. 1991 Sep;184(1):469-71. doi: 10.1016/0042-6822(91)90872-9.
Reassortants possessing the hemagglutinin (HA) gene from A/Equine/London/1416/73 (H7N7) [Eq/Lond] and five or more genes from A/Chicken/Pennsylvania/1370/83 (H5N2) [Ck/Penn] were lethal in chickens. This result demonstrates that horses can maintain influenza viruses whose HAs are capable of promoting virulence. Thus, reassortment of equine and avian influenza virus genes could generate viruses that might be lethal in domestic poultry.
携带来自A/Equine/London/1416/73（H7N7）[Eq/Lond]的血凝素（HA）基因以及来自A/Chicken/Pennsylvania/1370/83（H5N2）[Ck/Penn]的五个或更多基因的重配病毒对鸡具有致死性。这一结果表明，马能够维持其HA能够促进毒力的流感病毒。因此，马流感病毒基因与禽流感病毒基因的重配可能产生在家禽中具有致死性的病毒。
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