Salameh Shaden, Amitai Yona, Antopolsky Meir, Rott David, Stalnicowicz Ruth
Emergency Department, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
Clin Toxicol (Phila). 2009 Feb;47(2):137-41. doi: 10.1080/15563650801986711.
To describe the epidemiology of carbon monoxide (CO) poisoning in Jerusalem and identify risk factors for such poisoning.
A retrospective descriptive analysis of patients with CO poisoning who presented to the Hadassah hospitals in Jerusalem from 1994 to 2006.
All patients with suspected CO poisoning were examined and those with confirmed cases [carboxyhemoglobin (COHb) level >5%] were included. Sources of exposure, seasonal variation, and demographic characteristics were analyzed.
There were 292 patients (49% males) with 40 family clusters that accounted for 149 patients (51%); 230 patients (79%) presented during the winter months. All but one had unintentional CO intoxication. The main sources of exposure were faulty gas heaters (n = 135), fire (n = 102), and other residential heating systems (n = 40). The estimated annual incidence of CO poisoning decreased from 6.45 per 100,000 in 1994-2000 to 3.53 per 100,000 in 2001-2006. High-risk intoxication (COHb level >25%) occurred in 84 patients (29%). Factors associated with severe intoxication were male gender, individual patients (compared with those in clusters), and faulty gas heaters (compared with other sources).
Males exposed to CO may have a more severe intoxication. The lower risk in patients presenting in clusters could be explained by the assumption that severe presentation in one patient alerts the others who are less severely affected. The implementation of safer standards for residential heating systems and CO detectors together with the public education may explain the decline in the incidence of CO poisoning.
描述耶路撒冷一氧化碳(CO)中毒的流行病学特征并确定中毒的危险因素。
对1994年至2006年在耶路撒冷哈达萨医院就诊的CO中毒患者进行回顾性描述性分析。
所有疑似CO中毒的患者均接受检查,确诊病例(碳氧血红蛋白(COHb)水平>5%)纳入研究。分析暴露源、季节变化和人口统计学特征。
共有292例患者(49%为男性),其中40个家庭聚集性病例共149例(51%);230例患者(79%)在冬季就诊。除1例患者外,其余均为意外CO中毒。主要暴露源为有故障的燃气加热器(n = 135)、火灾(n = 102)和其他住宅供暖系统(n = 40)。估计CO中毒的年发病率从1994 - 2000年的每10万人6.45例降至2001 - 2006年的每10万人3.53例。84例患者(29%)发生高危中毒(COHb水平>25%)。与重度中毒相关的因素为男性、个体患者(与聚集性病例中的患者相比)以及有故障的燃气加热器(与其他暴露源相比)。
暴露于CO的男性可能中毒更严重。聚集性病例中患者风险较低可解释为,一名患者的严重症状会提醒其他受影响较轻的患者。住宅供暖系统更安全标准和CO探测器的实施以及公众教育可能解释了CO中毒发病率的下降。