Asane G S, Nirmal S A, Rasal K B, Naik A A, Mahadik M S, Rao Y Madhusudan
Department of Pharmaceutics, Pravara Rural College of Pharmacy, Loni, M.S., India.
Drug Dev Ind Pharm. 2008 Nov;34(11):1246-66. doi: 10.1080/03639040802026012.
To overcome the relatively short gastrointestinal (GI) time and improve localization for oral controlled or sustained release drug delivery systems, bioadhesive polymers that adhere to the mucin/epithelial surface are effective and lead to significant improvement in oral drug delivery. Improvements are also expected for other mucus-covered sites of drug administration. Bioadhesive polymers find application in the eye, nose, and vaginal cavity as well as in the GI tract, including the buccal cavity and rectum. This article lays emphasis mainly on mucoadhesive polymers, their properties, and their applications in buccal, ocular, nasal, and vaginal drug delivery systems with its evaluation methods.
为克服胃肠道（GI）转运时间相对较短的问题，并改善口服控释或缓释给药系统的定位，粘附于粘蛋白/上皮表面的生物粘附聚合物是有效的，并能显著改善口服给药。对于其他有黏液覆盖的给药部位也有望实现改善。生物粘附聚合物可应用于眼睛、鼻子、阴道腔以及胃肠道，包括口腔和直肠。本文主要重点介绍粘膜粘附聚合物、其性质，以及它们在口腔、眼部、鼻腔和阴道给药系统中的应用及其评价方法。
