Jensen P K, Hansen M K
Department of Ophthalmology, Kommunehospitalet, Aarhus University, Denmark.
Acta Ophthalmol (Copenh). 1991 Apr;69(2):178-86. doi: 10.1111/j.1755-3768.1991.tb02708.x.
Important prognostic information may be gained from knowing the volume of intraocular tumors, such as choroidal melanomas. To measure such volume, we developed an ultrasonographic 3-D scanning system, which operates by an axial, back and forth, half-turn rotation of a commercial sector scanning transducer, applied directly onto a closed eyelid. Control of movement, data acquisition, and image analysis are accomplished by means of a microcomputer and application-specific software. The elapsed time for scanning and digitizing 11 cross-sectional images across a human eyeball, is 4 sec. Outlines of specific structures are traced manually. The system was tested through repeated, in vitro measurements of known volumes of meat; the mean variation coefficient of these measurements was 2.8%. While accurate estimates were obtained on volumes between 0.01-0.25 ml, these are linearly dependent on gain setting. A patient with a choroidal melanoma was scanned repetitively. The procedures of scanning and tracing contributed about equally to the total variance. This method of scanning allows repeatable, reliable, and easily generated measurements of a tumor's volume and, thus, has great potential for use in the diagnosis and treatment of malignant, intraocular tumors.
通过了解眼内肿瘤（如脉络膜黑色素瘤）的体积，可获得重要的预后信息。为测量此类体积，我们开发了一种超声三维扫描系统，该系统通过将商用扇形扫描换能器轴向来回半圈旋转，直接应用于闭合的眼睑上进行操作。运动控制、数据采集和图像分析借助微型计算机和专用软件完成。扫描并数字化人眼球上11个横截面图像的耗时为4秒。特定结构的轮廓通过手动追踪。该系统通过对已知体积的肉块进行反复体外测量进行测试；这些测量的平均变异系数为2.8%。虽然在0.01 - 0.25毫升的体积范围内获得了准确估计值，但这些值与增益设置呈线性相关。对一名脉络膜黑色素瘤患者进行了重复扫描。扫描和追踪过程对总方差的贡献大致相同。这种扫描方法能够对肿瘤体积进行可重复、可靠且易于生成的测量，因此在恶性眼内肿瘤的诊断和治疗中具有巨大的应用潜力。
