He Cheng-Qiang, Han Guan-Zhu, Wang Dong, Liu Wei, Li Guo-Rong, Liu Xi-Ping, Ding Nai-Zheng
College of Life Science, Shandong Normal University, Shandong Province, Jinan 250014, China.
Virology. 2008 Oct 10;380(1):12-20. doi: 10.1016/j.virol.2008.07.014. Epub 2008 Aug 21.
Dynamic gene mutation and the reassortment of genes have been considered as the key factors responsible for influenza A virus virulence and host tropism change. This study reports several significant evidence demonstrating that homologous recombination also takes place between influenza A viruses in human and swine lineages. Moreover, in a mosaic descended from swine H1N1 subtype and human H2N2, we found that its minor putative parent might be a derivative from the human cold-adapted vaccine lineage, which suggests that live vaccine is capable of playing a role in genetic change of influenza A virus via recombination with circulating viruses. These results would be important for knowing the molecular mechanism of mammal influenza A virus heredity and evolution.
动态基因突变和基因重配已被视为甲型流感病毒毒力及宿主嗜性改变的关键因素。本研究报告了多项重要证据，证明甲型流感病毒在人和猪谱系之间也会发生同源重组。此外，在一株源自猪H1N1亚型和人H2N2的嵌合体病毒中，我们发现其可能的次要亲本可能是源自人冷适应疫苗谱系的衍生物，这表明活疫苗能够通过与流行病毒重组而在甲型流感病毒的基因变化中发挥作用。这些结果对于了解甲型流感病毒在哺乳动物中的遗传和进化分子机制具有重要意义。
