羟基磷灰石晶体的解聚

Disaggregation of hydroxyapatite crystals.

作者信息

Bisaz S, Felix R, Hansen N M, Fleisch H

出版信息

Biochim Biophys Acta. 1976 Dec 21;451(2):560-6. doi: 10.1016/0304-4165(76)90151-3.

Abstract

A system has been developed to measure quantitatively the disaggregation of hydroxyapatite crystals. Disaggregation was induced by pyrophosphate, ethane-1-hydroxy-1,1-diphosphonate, dichloromethylene diphosphonate, haparin and citrate. Hyaluronic acid stimulated aggregation at low concentrations and disaggregation at high concentrations. Lactate had no effect. The possible role disaggregation might play in the resorption of calcified tissues in vivo id discussed.

摘要

已开发出一种系统来定量测量羟基磷灰石晶体的分解。焦磷酸盐、乙烷-1-羟基-1,1-二膦酸盐、二氯亚甲基二膦酸盐、肝素和柠檬酸盐可诱导分解。透明质酸在低浓度时刺激聚集，在高浓度时刺激分解。乳酸没有作用。讨论了分解在体内钙化组织吸收中可能发挥的作用。