Sironi Laura, Williams John L, Moreno-Martin Ana M, Ramelli Paola, Stella Alessandra, Jianlin Han, Weigend Steffen, Lombardi Guerino, Cordioli Paolo, Mariani Paola
Parco Tecnologico Padano, CERSA, Polo Universitario, Lodi, Italy.
Virology. 2008 Oct 10;380(1):152-6. doi: 10.1016/j.virol.2008.07.022. Epub 2008 Aug 23.
Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection. Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the G allele, and two were segregating for A and G alleles. Birds in the other two lines were selected to be fixed for the A allele. Statistical analyses indicated that the Mx genotype did not affect the clinical status or the time course of infection after viral inoculation.
五条鸡品系被实验性感染高致病性禽流感H7N1病毒，以检测感染易感性的差异。三个品系对该病毒表现出高易感性，而两个品系表现出一定抗性，分别有20只鸡中的7只，以及15只鸡中的11只保持健康并在实验感染后存活下来。对Mx cDNA第2032位的G/A多态性进行基因分型显示，一个品系固定为G等位基因，两个品系A和G等位基因呈分离状态。另外两个品系的鸡被选择固定为A等位基因。统计分析表明，Mx基因型不影响病毒接种后的临床状态或感染进程。
