正常和转化缺陷型劳氏肉瘤病毒大分子RNA亚基3'末端区域的特征分析
Characterization of the 3'-terminal region of the large molecular weight RNA subunits from normal and transformation-defective Rous sarcoma virus.
作者信息
Pérez-Bercoff R, Billeter M A
出版信息
Biochim Biophys Acta. 1976 Dec 1;454(2):383-8. doi: 10.1016/0005-2787(76)90240-9.
PMID:187235
Abstract
In avian sarcoma viruses a function required to transform cells is frequently lost giving rise to non-transforming virus. The genetic information for this function is localized near the 3' end of the genome. Short 3'-terminal poly(A)-linked RNA fragments from the genomes of a transforming Rous sarcoma virus and its non-transforming derivative were isolated and gave rise to identical fingerprint patterns, suggesting that internal deletion rather than terminal elimination leads to non-transforming virus.
摘要
在禽肉瘤病毒中，细胞转化所需的功能常常丧失，从而产生非转化性病毒。该功能的遗传信息定位于基因组的3'端附近。从一种转化性劳氏肉瘤病毒及其非转化性衍生物的基因组中分离出短的3'末端多聚腺苷酸连接的RNA片段，它们产生相同的指纹图谱，这表明内部缺失而非末端消除导致了非转化性病毒。
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