Joseph Leena Dennis, Kuruvilla Sarah
Department of Pathology, Sri Ramachandra University, Chennai, Tamil Nadu, India.
Indian J Pathol Microbiol. 2008 Jul-Sep;51(3):402-4. doi: 10.4103/0377-4929.42534.
Lissencephaly is a malformation of the brain in which the brain surface is smooth, rather than convoluted. Among the various causes of lissencephaly, infection by a virus during pregnancy plays an important role. Cytomegalovirus (CMV) is an important pathogen causing this anomaly. We present this case of a young female with 24-week-gestation diagnosed on ultrasound as carrying an anomalous fetus with lissencephalic features. At autopsy, there were multiple intra-nuclear CMV inclusions in the brain and the kidneys. This case is presented for its rarity and for the documentation of the tissue localization of CMV inclusions at autopsy.
无脑回畸形是一种大脑畸形，其大脑表面平滑，而非呈脑回状。在无脑回畸形的各种病因中，孕期感染病毒起着重要作用。巨细胞病毒（CMV）是导致这种异常的重要病原体。我们报告一例妊娠24周的年轻女性病例，超声检查诊断为胎儿异常，具有无脑回特征。尸检时，在大脑和肾脏中发现多个核内CMV包涵体。报告该病例是因其罕见，并记录了尸检时CMV包涵体的组织定位。
