Amidzic J, Vuckovic N, Capo I, Levakov A F
University of Novi Sad, Faculty of Medicine, Department of Histology and Embryology, Clinical Centre of Vojvodina, Centre for Pathology and Histology, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
Malays J Pathol. 2019 Apr;41(1):75-78.
We report a case of congenital cytomegalovirus and Herpes simplex virus infection suspected via ultrasound indicated by the presence of fetal cerebral abnormalities. The pregnancy was electively terminated at 31 weeks of gestation. The postmortem examination of the foetus showed brain with lissencephaly. The histopathological examination revealed numerous enlarged cells containing cytomegalic inclusions and multinucleated giant cells in multiple fetal organs and placenta. Documented evidence of histopathological detection of cytomegalovirus inclusions in multiple organs are very sparse in literature. This case highlights the causal relationship of viral infections in early pregnancy and abnormalities of the central nervous system.
我们报告了一例先天性巨细胞病毒和单纯疱疹病毒感染病例，通过超声检查怀疑存在胎儿脑部异常。该妊娠在孕31周时选择性终止。胎儿尸检显示大脑无脑回。组织病理学检查显示多个胎儿器官和胎盘中有大量含有巨细胞包涵体的肿大细胞和多核巨细胞。文献中关于多个器官中巨细胞病毒包涵体组织病理学检测的记录证据非常稀少。该病例突出了妊娠早期病毒感染与中枢神经系统异常之间的因果关系。
