Fetissov Sergueï O, Hamze Sinno Maria, Coquerel Quentin, Do Rego Jean Claude, Coëffier Moïse, Gilbert Danièle, Hökfelt Tomas, Déchelotte Pierre
Digestive System and Nutrition Laboratory (ADEN EA3234), Institute of Biomedical Research, Rouen University, IFR23, Rouen, France.
Nutrition. 2008 Sep;24(9):854-9. doi: 10.1016/j.nut.2008.06.021.
Recent findings of autoantibodies directed against melanocortin peptides suggest that these autoantibodies may represent a source of variability in peptidergic signaling that can be responsible for altered appetite and emotion in eating disorders. However, it is still unknown if autoantibodies directed against some other appetite-regulating neuropeptides and peptide hormones exist in healthy human subjects and if these autoantibodies can regulate appetite and emotion.
We determined the presence of autoantibodies against some key appetite-regulating neuropeptides and peptide hormones in sera of human subjects and in rats, and used animal models to study the role of alpha-melanocyte-stimulating hormone autoantibodies in food intake and anxiety.
Immunoglobulin G and A autoantibodies against alpha-melanocyte-stimulating hormone, neuropeptide Y, agouti-related protein, ghrelin, leptin, and some other neuropeptides or peptide hormones involved in appetite control were present in healthy humans and rats. Animal models including active and passive transfer showed that alpha-melanocyte-stimulating hormone autoantibodies are involved in the regulation of feeding and anxiety. Sequence homology was found between neuropeptides and proteins from some members of intestinal microflora, whereas germ-free rats showed altered levels of autoantibodies directed against several neuropeptides.
Autoantibodies directed against appetite-regulating neuropeptides and peptide hormones are emerging as important participants in the peptidergic mechanisms controlling motivated behavior. Furthermore, these autoantibodies could provide a link in the gut-brain axis and may represent new biological targets for the diagnosis and treatment of eating disorders.
最近针对黑皮质素肽的自身抗体研究结果表明，这些自身抗体可能是肽能信号变异性的一个来源，可导致饮食失调中食欲和情绪的改变。然而，健康人类受试者中是否存在针对其他一些食欲调节神经肽和肽激素的自身抗体，以及这些自身抗体是否能调节食欲和情绪，目前仍不清楚。
我们测定了人类受试者和大鼠血清中针对一些关键食欲调节神经肽和肽激素的自身抗体的存在情况，并使用动物模型研究α-黑素细胞刺激素自身抗体在食物摄入和焦虑中的作用。
健康人和大鼠体内存在针对α-黑素细胞刺激素、神经肽Y、刺鼠相关蛋白、胃饥饿素、瘦素以及其他一些参与食欲控制的神经肽或肽激素的免疫球蛋白G和A自身抗体。包括主动和被动转移在内的动物模型表明，α-黑素细胞刺激素自身抗体参与进食和焦虑的调节。在肠道微生物群的一些成员的神经肽和蛋白质之间发现了序列同源性，而无菌大鼠针对几种神经肽的自身抗体水平发生了改变。
针对食欲调节神经肽和肽激素的自身抗体正在成为控制动机行为的肽能机制中的重要参与者。此外，这些自身抗体可能在肠-脑轴中起到联系作用，并且可能代表饮食失调诊断和治疗的新生物学靶点。
