Iakovlev M Iu, Zubairova L D, Krupnik A N, Permiakov N K
Arkh Patol. 1991;53(4):3-8.
Alveolar macrophages (AM) represent a lung border system bringing about the protection of the organ from the environmental hazards, regulating cell and humoral response in the lungs, and eliminating endogenous toxic substances. However, in some situations AM are involved in the pathologic processes and even may serve as an initiating factor in the development of lung pathology. They realize their pathogenic effect in the bronchial asthma, acute respiratory distress-syndrome, pneumoconiosis releasing various biologically active compounds which take part in the formation of bronchial hyperreactivity, chemotaxis disturbances, haemostasis pathology. Particularly interesting is the possibility of lung tissue damage by AM when they interact with endotoxin-positive granulocytes.
肺泡巨噬细胞（AM）是肺部的一种边界防御系统，可保护肺部免受环境危害，调节肺部的细胞和体液反应，并清除内源性有毒物质。然而，在某些情况下，肺泡巨噬细胞会参与病理过程，甚至可能成为肺部病理发展的起始因素。它们在支气管哮喘、急性呼吸窘迫综合征、尘肺等疾病中发挥致病作用，释放各种生物活性化合物，参与支气管高反应性、趋化紊乱、止血病理的形成。特别值得关注的是，当肺泡巨噬细胞与内毒素阳性粒细胞相互作用时，可能会对肺组织造成损伤。
