Coutinho Evandro S F, Fletcher Astrid, Bloch Katia V, Rodrigues Laura C
Department of Epidemiology, National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
BMC Geriatr. 2008 Aug 26;8:21. doi: 10.1186/1471-2318-8-21.
Fracture after falling has been identified as an important problem in public health. Most studies of risk factors for fractures due to falls have been carried out in developed countries, although the size of the elderly population is increasing fast in middle income countries. The objective of this paper is to identify risk factors for fall related to severe fractures in those aged 60 or more in a middle-income country.
A case-control study was carried out in Rio de Janeiro-Brazil based general hospitals between 2002-2003. Two hundred-fifty hospitalised cases of fracture were matched with 250 community controls by sex, age group and living area. Data were collected for socio-demographic variables, health status and drugs used before the fall. A conditional logistic regression model was fitted to identify variables associated with the risk of fall related severe fracture.
Low body mass index, cognitive impairment, stroke and lack of urine control were associated with increased risk of severe fall related fractures. Benzodiazepines and muscle relaxants were also related to an increased risk of severe fractures while moderate use of alcohol was associated with reduced risk.
Although the association between benzodiazepines and fractures due to fall has been consistently demonstrated for old people, this has not been the case for muscle relaxant drugs. The decision to prescribe muscle relaxants for elderly people should take into account the risk of severe fracture associated with these drugs.
跌倒后骨折已被确认为一个重要的公共卫生问题。尽管中等收入国家老年人口规模增长迅速,但大多数关于跌倒所致骨折风险因素的研究是在发达国家开展的。本文的目的是确定一个中等收入国家60岁及以上人群中与严重骨折相关的跌倒风险因素。
2002年至2003年期间,在巴西里约热内卢的综合医院开展了一项病例对照研究。250例住院骨折病例按性别、年龄组和居住地区与250名社区对照进行匹配。收集了社会人口统计学变量、健康状况以及跌倒前使用药物的数据。采用条件逻辑回归模型来确定与跌倒相关严重骨折风险相关的变量。
低体重指数、认知障碍、中风和尿失禁与跌倒相关严重骨折风险增加有关。苯二氮䓬类药物和肌肉松弛剂也与严重骨折风险增加有关,而适度饮酒则与风险降低有关。
尽管苯二氮䓬类药物与老年人跌倒所致骨折之间的关联已得到一致证实,但肌肉松弛剂药物并非如此。为老年人开具肌肉松弛剂时应考虑到这些药物与严重骨折相关的风险。