Liang Y, Kociok N, Leszczuk M, Hiebl W, Theisinger B, Lux A, Joussen A M
Department of Ophthalmology, University of Düsseldorf, Düsseldorf, Germany.
Br J Ophthalmol. 2008 Nov;92(11):1522-7. doi: 10.1136/bjo.2008.143750. Epub 2008 Aug 26.
The aim of the study was to compare the efficacy of perfluorobutylpentane (F4H5) and perfluorohexyloctane (F6H8) in dissolving silicone oil from the surface of silicone intraocular lenses (IOL).
Droplets of stained silicone oil were applied to an object slide either lying flat or tilted by 30 degrees . Mixing with H(2)O, F4H5 or F6H8 was documented by a digital camera. Droplets of silicone oil were applied to silicone lenses and washed off by repeated rinsing with F4H5 or F6H8. The silicone lenses of 11 patients with silicone oil remnants on the posterior IOL surface were rinsed intraoperatively with F4H5 during removal surgery.
Only F4H5 was able to mix with silicone oil and to remove it form the surface of a glass object slides. Rinsing with 25 mul F4H5 reduced the amount of silicone oil 1000 mPas or 5000 mPas attached on a silicone lens to 15% and 28%, respectively. A hanging droplet of silicone oil 5000 beneath a silicone lens was completely removed from below by F4H5. In all patients sufficient IOL cleaning was possible using F4H5. There was no significant postoperative inflammation in the vitreous or anterior chamber.
Polydimethylsiloxanes dissolve effectively in F4H5 due to its lipophilic chemical structure. A much smaller volume of F4H5 than F6H8 is able to remove silicone oil from silicone lenses completely. Intraocular use of F4H5 is safe, and initial clinical data underlines its effectiveness as a cleaning agent after contact of silicone lenses with silicone oil.
本研究旨在比较全氟丁基戊烷（F4H5）和全氟己基辛烷（F6H8）溶解硅水凝胶人工晶状体（IOL）表面硅油的效果。
将染色的硅油滴液滴在平放或倾斜30度的载玻片上。用数码相机记录其与水、F4H5或F6H8混合的情况。将硅油滴液滴在硅水凝胶镜片上，并用F4H5或F6H8反复冲洗以去除。在11例后IOL表面残留硅油的患者的手术中，在取出手术期间用F4H5冲洗硅水凝胶镜片。
只有F4H5能够与硅油混合并从玻璃载玻片表面去除它。用25微升F4H5冲洗可将附着在硅水凝胶镜片上1000毫帕斯卡或5000毫帕斯卡的硅油量分别减少至15%和28%。硅水凝胶镜片下方5000毫帕斯卡的硅油悬滴被F4H5从下方完全去除。在所有患者中，使用F4H5都能够充分清洁IOL。玻璃体或前房术后无明显炎症。
由于其亲脂性化学结构，聚二甲基硅氧烷可有效溶解于F4H5中。F4H5的用量比F6H8小得多就能完全从硅水凝胶镜片上去除硅油。眼内使用F4H5是安全的，初步临床数据表明其作为硅水凝胶镜片与硅油接触后的清洁剂是有效的。
