Marrie Ra, Horwitz R, Cutter G, Tyry T, Campagnolo D, Vollmer T
Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Mult Scler. 2008 Sep;14(8):1091-8. doi: 10.1177/1352458508092263.
Multiple sclerosis (MS) is associated with substantial morbidity. The impact of comorbidity on MS is unknown, but comorbidity may explain some of the unpredictable progression. Comorbidity is common in the general population, and is associated with adverse health outcomes. To begin understanding the impact of comorbidity on MS, we need to know the breadth, type, and frequencies of comorbidities among MS patients. Using the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry, we aimed to describe comorbidities and their demographic predictors in MS.
In October 2006, we queried NARCOMS participants regarding physical comorbidities. Of 16,141 participants meeting the inclusion criteria, 8983 (55.7%) responded.
Comorbidity was relatively common; if we considered conditions which are very likely to be accurately self-reported, then 3280 (36.7%) reported at least one physical comorbidity. The most frequently reported comorbidities were hypercholesterolemia (37%), hypertension (30%), and arthritis (16%). Associated with the risk of comorbidity were being male [females vs. males, odds ratio (OR) 0.77; 0.69-0.87]; age (age >60 years vs. age < or = 44 years, OR 5.91; 4.95-7.06); race (African Americans vs. Whites, OR 1.46; 1.06-2.03); and socioeconomic status (Income <$15,000 vs. Income >$100,000, OR 1.37; 1.10-1.70).
Comorbidity is common in MS and similarly associated with socioeconomic status.
多发性硬化症（MS）会导致严重的发病情况。合并症对MS的影响尚不清楚，但合并症可能是部分不可预测病情进展的原因。合并症在普通人群中很常见，且与不良健康结果相关。为了开始了解合并症对MS的影响，我们需要知晓MS患者中合并症的范围、类型及发生频率。利用北美多发性硬化症研究委员会（NARCOMS）登记处的数据，我们旨在描述MS患者的合并症情况及其人口统计学预测因素。
2006年10月，我们就身体合并症情况对NARCOMS的参与者进行了询问。在16141名符合纳入标准的参与者中，有8983人（55.7%）进行了回复。
合并症相对常见；如果我们考虑那些很可能被准确自我报告的疾病，那么有3280人（36.7%）报告至少有一种身体合并症。报告最频繁的合并症是高胆固醇血症（37%）、高血压（30%）和关节炎（16%）。与合并症风险相关的因素有男性（女性与男性相比，比值比[OR]为0.77；0.69 - 0.87）；年龄（年龄>60岁与年龄≤44岁相比，OR为5.91；4.95 - 7.06）；种族（非裔美国人与白人相比，OR为1.46；1.06 - 2.03）；以及社会经济地位（收入<$15,000与收入>$100,000相比，OR为1.37；1.10 - 1.70）。
合并症在MS患者中很常见，且同样与社会经济地位相关。
