Fish Eleanor N
Toronto General Research Institute, University Health Network, Department of Immunology, University of Toronto, Women's College Research Institute, Ontario, Canada.
Nat Rev Immunol. 2008 Sep;8(9):737-44. doi: 10.1038/nri2394.
Despite accumulating evidence in support of sex-based differences in innate and adaptive immune responses, in the susceptibility to infectious diseases and in the prevalence of autoimmune diseases, health research and clinical practice do not address these distinctions, and most research studies of immune responses do not stratify by sex. X-linked genes, hormones and societal context are among the many factors that contribute to disparate immune responses in males and females. It is crucial to address sex-based differences in disease pathogenesis and in the pharmacokinetics and pharmacodynamics of therapeutic medications to provide optimal disease management for both sexes.
尽管越来越多的证据支持在先天性和适应性免疫反应、传染病易感性以及自身免疫性疾病患病率方面存在基于性别的差异，但健康研究和临床实践并未考虑这些差异，而且大多数免疫反应研究也未按性别进行分层。X连锁基因、激素和社会环境是导致男性和女性免疫反应不同的众多因素之一。在疾病发病机制以及治疗药物的药代动力学和药效学方面考虑基于性别的差异，对于为两性提供最佳疾病管理至关重要。
