LKB1在肺癌发展中的作用。
Role of LKB1 in lung cancer development.
作者信息
Makowski L, Hayes D N
机构信息
Division of Endocrinology, Department of Medicine, Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Metabolism, and Nutrition, Durham, NC, USA.
出版信息
Br J Cancer. 2008 Sep 2;99(5):683-8. doi: 10.1038/sj.bjc.6604515. Epub 2008 Aug 19.
Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS activation allows for unchecked growth and the metabolic capacity to accommodate the proliferation.
三种表型相关的遗传综合征及其病变（LKB1、PTEN和TSC1/2）被确定在肺癌中经常发生改变。LKB1是一种在30%的肺癌中失活的激酶，本文对此进行了讨论。LKB1调节的丧失通常与KRAS激活同时发生，从而导致不受控制的生长以及适应增殖的代谢能力。
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