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八旬老人的颈动脉血管成形术和支架置入术:安全吗?

Carotid angioplasty and stenting in octogenarians: is it safe?

作者信息

Henry M, Henry I, Polydorou A, Hugel M

机构信息

Cabinet de Cardiologie, Nancy, France.

Global Research Institute, Apollo Clinic, Hyderabad, India.

出版信息

Catheter Cardiovasc Interv. 2008 Sep 1;72(3):309-317. doi: 10.1002/ccd.21574.

Abstract

PURPOSE

Elderly patients have a higher risk of complications in carotid endarterectomy. The aim of the study was to evaluate whether carotid artery stenting (CAS) performed in octogenarians also increases the procedure related risk.

METHODS

870 patients (male 626) mean age 70.9 +/- 9.3 years underwent 930 CAS for de novo lesions (n = 851) restenoses (n = 54) post radiation (n = 14) inflammatory arteritis (n = 9) post trauma aneurysms (n = 2). Indications for treatment: symptomatic carotid stenosis > or = 70% (n = 577) or asymptomatic stenosis > or = 80%. Patients were separated into two age groups: <80 years (749 patients, 806 CAS) and >80 years (121 patients, 124 CAS). 187 CAS performed without protection (N.P-) 6 patients >80 years, 743 with protection (NP+) (occlusion balloon: 334, filters: 404, reversal flow: 6) 118 patients >80 years. Data analysis included neurological complications, death and myocardial infarction (MI) rate at 30 days, anatomical particularities. Technical points will be described depending on the age of the patient.

RESULTS

Technical success 804/806 in patients <80 years, 123/124 in patients >80 years (NS). 30 days outcomes: in the patient group <80 years we observed 9 TIA (1.1%) 3 without NP (1.7%) 6 with NP (0.9%), 5 minor strokes (0.6%) 2 without NP (1.1%) 3 with NP (0.5%), 3 major strokes: 2 without NP (1.1%) 1 with NP (0.2%), 5 deaths (0.6%) 2 without NP (1.1%) 3 with NP (0.5%). Death/stroke/MI: 14 (1.8%) 6 without NP (3.3%), 8 with NP (1.3%). In the group >80 years, we observed 2 TIA (1.7%) 1 without NP 1 with NP (0.92%) 1 minor stroke without NP (17%) no major stroke, no death. Death/stroke/MI 1 without NP (17%).

CONCLUSION

CAS can be performed in elderly patients without higher risk than in younger patients. But good indications, a meticulous technique, protection devices are mandatory and some technical points must be pointed out to avoid neurological complications and failures.

摘要

目的

老年患者行颈动脉内膜切除术时并发症风险更高。本研究旨在评估在八旬老人中进行颈动脉支架置入术(CAS)是否也会增加手术相关风险。

方法

870例患者(男性626例),平均年龄70.9±9.3岁,因新发病变(n = 851)、再狭窄(n = 54)、放疗后(n = 14)、炎性动脉炎(n = 9)、创伤后动脉瘤(n = 2)接受了930例CAS。治疗指征:有症状的颈动脉狭窄≥70%(n = 577)或无症状狭窄≥80%。患者被分为两个年龄组:<80岁(749例患者,806例CAS)和>80岁(121例患者,124例CAS)。187例CAS未进行保护(N.P-),其中>80岁患者6例;743例进行了保护(NP+)(闭塞球囊:334例,滤网:404例,逆流:6例),其中>80岁患者118例。数据分析包括30天时的神经并发症、死亡和心肌梗死(MI)发生率以及解剖学特点。将根据患者年龄描述技术要点。

结果

<80岁患者中技术成功率为804/806,>80岁患者中为123/124(无显著性差异)。30天的结果:在<80岁的患者组中,我们观察到9例短暂性脑缺血发作(TIA)(1.1%),其中3例未进行保护(1.7%),6例进行了保护(0.9%);5例轻度卒中(0.6%),其中2例未进行保护(1.1%),3例进行了保护(0.5%);3例重度卒中:2例未进行保护(1.1%),1例进行了保护(0.2%);5例死亡(0.6%),其中2例未进行保护(1.1%),3例进行了保护(0.5%)。死亡/卒中/MI:14例(1.8%),6例未进行保护(3.3%),8例进行了保护(1.3%)。在>80岁的组中,我们观察到2例TIA(1.7%),1例未进行保护,1例进行了保护(0.92%);1例未进行保护的轻度卒中(17%),无重度卒中,无死亡。死亡/卒中/MI 1例未进行保护(17%)。

结论

老年患者行CAS时风险并不高于年轻患者。但需要有良好的指征、细致的技术、保护装置,并且必须指出一些技术要点以避免神经并发症和手术失败。

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