Ogura Y, Suzuki T, Yamamoto Y, Ogura M
Department of Biochemistry, Faculty of Medicine, Tottori University, Yonago.
Biol Chem Hoppe Seyler. 1991 May;372(5):345-9. doi: 10.1515/bchm3.1991.372.1.345.
The effect of treatment with vanadate on the metabolism of bile acids was studied in normal and diabetic rats. In the normal rats, the composition of biliary bile acids was not changed by drinking an aqueous solution of 0.2 g/l NaVO3-5 g/l NaCl ad libitum for two weeks. By contrast, the increased proportion of cholic acid, accounting for 88% of the total biliary bile acids, in the diabetic rats decreased to 46% by the treatment with vanadate without any elevation of serum insulin level. These results indicate that vanadate with an insulin-like effect on glucose metabolism in diabetic rats has such an effect also on bile acid metabolism in an insulin-deficient state.
在正常大鼠和糖尿病大鼠中研究了钒酸盐治疗对胆汁酸代谢的影响。在正常大鼠中，随意饮用含0.2 g/l NaVO₃ - 5 g/l NaCl的水溶液两周后，胆汁胆汁酸的组成没有变化。相比之下，糖尿病大鼠中占总胆汁胆汁酸88%的胆酸比例增加，经钒酸盐治疗后降至46%，而血清胰岛素水平未升高。这些结果表明，钒酸盐对糖尿病大鼠的葡萄糖代谢具有胰岛素样作用，在胰岛素缺乏状态下对胆汁酸代谢也有这种作用。
