Wey H E, Yunker R L, Harris P, Subbiah M T
Biochem Med. 1984 Apr;31(2):167-73. doi: 10.1016/0006-2944(84)90021-8.
The effect of streptozotocin-induced diabetes in neonatal rat on the bile acid pool and composition during adult life was investigated. Unlike the effect of diabetes in adult rats (where bile acid pool increases markedly), neonatal diabetes caused a reduction in bile acid pool in adult life in females (but not in males) with significant reduction in both cholic and chenodeoxycholic acids. Upon challenge with dietary cholesterol, only the female diabetic rat responded with a further reduction in total bile acid pool. These studies demonstrate a selective sensitivity in the female diabetic rat with regard to diabetes-induced changes in bile acid pool.
研究了链脲佐菌素诱导的新生大鼠糖尿病对成年期胆汁酸池和组成的影响。与成年大鼠糖尿病的影响（胆汁酸池显著增加）不同，新生期糖尿病导致成年雌性大鼠（而非雄性大鼠）的胆汁酸池减少，胆酸和鹅去氧胆酸均显著降低。在给予膳食胆固醇刺激后，只有雌性糖尿病大鼠的总胆汁酸池进一步减少。这些研究表明，雌性糖尿病大鼠对糖尿病诱导的胆汁酸池变化具有选择性敏感性。
