Sun M, Li Y, Zhang J, Bian J
Institute of Basic Medical Sciences, Harbin Medical University.
Zhen Ci Yan Jiu. 1991;16(1):19-22.
The somatic and visceral noxious stimuli could simultaneously induce the increase of discharges of pain-excitation neurons (PEN) and the decrease of discharges of pain-inhibition neurons (PIN) in the Nucleus Ventralis posterolalis (VPL) of thalamus in the rat, and the electric activities of the two kinds of neurons cooperated each other. By the injection of morphine (5 mg/kg) and the electroacupuncture of "zusanli", the discharges of PEN were reduced and the discharges of PIN were enhanced. The results suggested that VPL of thalamus in the rat be involved in the modulating action on pain sensation and the analgesic effects of morphine and electroacupuncture by the simultaneous electric activities of PEN and PIN in VPL.
躯体和内脏伤害性刺激可同时诱发大鼠丘脑腹后外侧核(VPL)中痛觉兴奋神经元(PEN)放电增加和痛觉抑制神经元(PIN)放电减少,且两类神经元的电活动相互协同。注射吗啡(5毫克/千克)和电针“足三里”后,PEN放电减少,PIN放电增强。结果提示,大鼠丘脑VPL通过VPL中PEN和PIN的同步电活动参与对痛觉的调制作用以及吗啡和电针的镇痛效应。