Fukunaga M, Miller M M, Deftos L J
Department of Medicine, University of California, San Diego.
Horm Metab Res. 1991 Apr;23(4):166-7. doi: 10.1055/s-2007-1003642.
We have demonstrated that liposomally entrapped calcitonin (CT) and parathyroid hormone (PTH) can be orally effective in regulating blood calcium. Liposomal CT produced hypocalcemia and liposomal PTH produced hypercalcemia upon oral administration to rats. Specific liposomal formulations were necessary to affect the appropriate decrease and increase in blood calcium concentration. Future extension of these studies may lead to clinically valuable forms of liposomal-peptide preparations.
我们已经证明，脂质体包裹的降钙素（CT）和甲状旁腺激素（PTH）口服后可有效调节血钙水平。给大鼠口服脂质体CT会导致血钙降低，口服脂质体PTH会导致血钙升高。需要特定的脂质体制剂才能使血钙浓度适当降低和升高。这些研究的进一步拓展可能会产生具有临床价值的脂质体-肽制剂形式。
