Remla A, Menon P V, Kurup P A, Kumari S
Department of Biochemistry, University of Kerala, Trivandrum, India.
Indian J Exp Biol. 1991 Mar;29(3):244-8.
Effect of ethanol administration on the severity of myocardial infarction induced by isoproterenol in rats was studied. Even though serum CPK and GOT levels as well as the extent of myocardial damage as revealed by histopathological studies, were similar, the survival rate was higher in rats administered ethanol. Concentration of cholesterol and triglycerides in the serum and heart in rats given ethanol and isoproterenol seems to be the additive effect caused individually by ethanol and isoproterenol. Myocardial alcohol dehydrogenase and aldehyde dehydrogenase both showed increased activity in rats treated with ethanol. The rate of recovery from myocardial infarction however, was slower in rats treated with ethanol as judged from the serum CPK value.
研究了给予乙醇对异丙肾上腺素诱导的大鼠心肌梗死严重程度的影响。尽管血清肌酸磷酸激酶（CPK）和谷草转氨酶（GOT）水平以及组织病理学研究显示的心肌损伤程度相似，但给予乙醇的大鼠存活率更高。给予乙醇和异丙肾上腺素的大鼠血清和心脏中的胆固醇和甘油三酯浓度似乎是乙醇和异丙肾上腺素分别产生的相加作用。心肌乙醇脱氢酶和醛脱氢酶在给予乙醇的大鼠中均显示活性增加。然而，从血清CPK值判断，给予乙醇的大鼠心肌梗死的恢复速度较慢。
