• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Epidermal growth factor reduces resistance to doxorubicin.

作者信息

Kwok T T, Sutherland R M

机构信息

Laboratory of Cell and Molecular Biology, SRI International, Menlo Park, CA 94025.

出版信息

Int J Cancer. 1991 Aug 19;49(1):73-6. doi: 10.1002/ijc.2910490114.

DOI:10.1002/ijc.2910490114
PMID:1874574
Abstract

Epidermal growth factor (EGF) increased the sensitivity to doxorubicin (DOX) of a human squamous carcinoma cell line, A431. The relative enhancement of sensitivity by EGF was greater in 2 DOX-resistant sublines, A431/A5 and A431/A10, established by growing cells from surviving colonies after treatment of A431 cells with DOX. A greater number of EGF receptors (both high- and low-affinity binding sites) was found for resistant A431/A5 and A431/A10 cells than for parental cells. The enhanced drug responsiveness is not directly related to EGF effects on growth, as growth inhibition by EGF appears to be similar among the 3 sublines.

摘要

相似文献

1
Epidermal growth factor reduces resistance to doxorubicin.
Int J Cancer. 1991 Aug 19;49(1):73-6. doi: 10.1002/ijc.2910490114.
2
Quantitative differences in the effects of mouse and human epidermal growth factors on A431 human tumor cells.小鼠和人表皮生长因子对A431人肿瘤细胞作用的定量差异。
Cancer Lett. 1987 Nov;37(3):241-9. doi: 10.1016/0304-3835(87)90108-x.
3
Conversion of epidermal growth factor (EGF) into a stimulatory ligand for A431-cell growth by herbimycin A by decreasing the level of expression of EGF receptor.通过降低表皮生长因子（EGF）受体的表达水平，除草菌素A将表皮生长因子（EGF）转化为A431细胞生长的刺激配体。
Biochem J. 1994 Jul 1;301 ( Pt 1)(Pt 1):57-62. doi: 10.1042/bj3010057.
4
Differences in EGF related radiosensitisation of human squamous carcinoma cells with high and low numbers of EGF receptors.具有高、低表皮生长因子（EGF）受体数量的人鳞状癌细胞在EGF相关放射增敏作用方面的差异。
Br J Cancer. 1991 Aug;64(2):251-4. doi: 10.1038/bjc.1991.286.
5
The relationship between epidermal growth factor receptors and the terminal differentiation of A431 carcinoma cells.表皮生长因子受体与A431癌细胞终末分化之间的关系。
Biochem Biophys Res Commun. 1986 Nov 14;140(3):837-43. doi: 10.1016/0006-291x(86)90710-2.
6
Reduced growth rate accompanied by aberrant epidermal growth factor signaling in drug resistant human breast cancer cells.耐药性人乳腺癌细胞中生长速率降低并伴有异常的表皮生长因子信号传导。
Biochim Biophys Acta. 2000 Jul 21;1497(2):215-26. doi: 10.1016/s0167-4889(00)00062-8.
7
Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies.阿霉素与抗表皮生长因子受体单克隆抗体联合使用的抗肿瘤作用。
J Natl Cancer Inst. 1993 Aug 18;85(16):1327-33. doi: 10.1093/jnci/85.16.1327.
8
Membrane vesicles of A431 cells contain one class of epidermal growth factor binding sites.A431细胞的膜泡含有一类表皮生长因子结合位点。
Biochim Biophys Acta. 1990 May 22;1052(3):453-60. doi: 10.1016/0167-4889(90)90155-7.
9
Photocytotoxic action of EGF-PVA-Sn(IV)chlorin e6 and EGF-dextran-Sn(IV)chlorin e6 internalizable conjugates on A431 cells.表皮生长因子-聚乙烯醇-四价锡二氢卟吩e6和表皮生长因子-葡聚糖-四价锡二氢卟吩e6可内化共轭物对A431细胞的光细胞毒性作用。
Int J Oncol. 1998 Dec;13(6):1171-7. doi: 10.3892/ijo.13.6.1171.
10
Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.表皮生长因子对A431细胞的生长刺激作用：利用抗受体单克隆抗体鉴定表皮生长因子的高亲和力受体
Proc Natl Acad Sci U S A. 1983 Mar;80(5):1337-41. doi: 10.1073/pnas.80.5.1337.

引用本文的文献

1
Synthesis and characterization of a novel pH-responsive drug-releasing nanocomposite hydrogel for skin cancer therapy and wound healing.新型 pH 响应型释药纳米复合水凝胶的合成与表征及其在皮肤癌治疗和伤口愈合中的应用。
J Mater Chem B. 2021 Dec 1;9(46):9533-9546. doi: 10.1039/d1tb01934a.
2
Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells.姜烯酚和虾青素对阿霉素细胞毒性的表观遗传免疫调节作用在激素阳性乳腺癌细胞中。
BMC Pharmacol Toxicol. 2021 Jan 28;22(1):8. doi: 10.1186/s40360-021-00473-2.
3
Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR.
非编码RNA CUDR诱导人类癌细胞产生耐药性及发生转化
RNA. 2007 Jun;13(6):890-8. doi: 10.1261/rna.359007. Epub 2007 Apr 6.
4
Cellular responses to EGFR inhibitors and their relevance to cancer therapy.细胞对表皮生长因子受体（EGFR）抑制剂的反应及其与癌症治疗的相关性。
Cancer Lett. 2007 Sep 8;254(2):165-77. doi: 10.1016/j.canlet.2007.02.006. Epub 2007 Mar 23.
5
Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein.在表达突变蛋白的共济失调毛细血管扩张症细胞中，表皮生长因子对共济失调毛细血管扩张症突变蛋白激酶（ATM）的转录下调存在缺陷。
Oncogene. 2001 Jul 19;20(32):4281-90. doi: 10.1038/sj.onc.1204527.
6
Prognostic value of a solubilized fraction of EGF receptors in primary breast cancer using an immunoenzymatic assay--a retrospective study.
Breast Cancer Res Treat. 1994 Jan;29(1):85-95. doi: 10.1007/BF00666184.
7
Drug and radiation resistance in spheroids: cell contact and kinetics.球体中的药物和辐射抗性：细胞接触与动力学
Cancer Metastasis Rev. 1994 Jun;13(2):121-38. doi: 10.1007/BF00689632.