Wu Y, Zhao Q, Anderson J M, Hiltner A, Lodoen G A, Payet C R
Department of Macromolecular Science, Case Western Reserve University, Cleveland, Ohio 44106.
J Biomed Mater Res. 1991 Jun;25(6):725-39. doi: 10.1002/jbm.820250604.
Four materials based on a single poly-(etherurethane) (PEU) prepared from MDI and PTMEG but differing in additives were studied in the cage implant system. The two additives studied were Santowhite powder at the 1% level and Methacrol 2138F 5%. Methacrol 2138F appeared to be immiscible with the base PEU and was dispersed in discrete domains about 0.5-micron in size. The retrieved PEU specimens were also cleaned and examined in the optical and scanning electron microscopes, and the size and density of adherent foreign body giant cells (FBGCs) were measured at implantation times up to 10 weeks. Methacrol 2138F had no effect on the density, coverage or size distribution of adherent FBGCs, but leaching of Methacrol 2138F was considered to be responsible for extensive pitting of the PEU surface. On the other hand, Santowhite powder appeared to inhibit formation of FBGCs, and while surface cracking and flaking were observed as early as 3 weeks postimplantation on some PEUs, the Santowhite powder effectively inhibited surface cracking and flaking up to the longest implantation time studied.
在笼式植入系统中研究了四种基于由二苯基甲烷二异氰酸酯（MDI）和聚四氢呋喃（PTMEG）制备的单一聚醚聚氨酯（PEU）但添加剂不同的材料。所研究的两种添加剂分别是1%含量的Santowhite粉末和5%的甲基丙烯酸甲酯2138F。甲基丙烯酸甲酯2138F似乎与基础PEU不相容，并以约0.5微米大小的离散区域分散。回收的PEU样本也进行了清洗，并在光学显微镜和扫描电子显微镜下进行检查，在长达10周的植入时间测量附着的异物巨细胞（FBGCs）的大小和密度。甲基丙烯酸甲酯2138F对附着的FBGCs的密度、覆盖率或大小分布没有影响，但甲基丙烯酸甲酯2138F的浸出被认为是PEU表面出现大量麻点的原因。另一方面，Santowhite粉末似乎抑制了FBGCs的形成，虽然在一些PEU植入后3周就观察到表面开裂和剥落，但Santowhite粉末在研究的最长植入时间内有效抑制了表面开裂和剥落。
