Hoang Ngoc M H, Park Kwangsik
College of Pharmacy, Dongduk Women's University, Seoul 02748, Republic of Korea.
Toxics. 2024 Nov 29;12(12):869. doi: 10.3390/toxics12120869.
Tert-butyl phenolic antioxidants (TBP-AOs) are employed to inhibit oxidation and function as stabilizers and protectants in a broad spectrum of consumer products, such as food packaging, adhesives, lubricants, plastics, and cosmetics. The extensive utilization of TBP-AOs results in human exposure through various pathways. Furthermore, some TBP-AOs have been identified as potential endocrine disruptors and may cause liver and lung damage, as well as allergic reactions. Considering their varied applications and potential toxicity, a detailed evaluation of their safety profiles is imperative. However, existing research is often segmented and tends to focus narrowly on specific compounds. Consequently, this review collates recent data on TBP-AOs regarding their production, exposure, and toxicity, incorporating different databases and prior studies, as well as predictions of toxicity using ADMET. Our review strives to offer a comprehensive overview of the characteristics and health effects of TBP-AOs to guide future research and inform policy decisions.
叔丁基酚类抗氧化剂（TBP-AOs）被用于抑制氧化，并在广泛的消费品中作为稳定剂和保护剂，如食品包装、粘合剂、润滑剂、塑料和化妆品。TBP-AOs的广泛使用导致人类通过各种途径接触到它们。此外，一些TBP-AOs已被确定为潜在的内分泌干扰物，可能会导致肝脏和肺部损伤以及过敏反应。考虑到它们的多种应用和潜在毒性，对其安全性进行详细评估势在必行。然而，现有研究往往是分散的，并且倾向于狭隘地关注特定化合物。因此，本综述整理了关于TBP-AOs的生产、接触和毒性的最新数据，纳入了不同的数据库和先前的研究，以及使用ADMET进行的毒性预测。我们的综述力求全面概述TBP-AOs的特性和健康影响，以指导未来的研究并为政策决策提供信息。
