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1,25-二羟胆钙化醇抑制Gc（维生素D结合蛋白）的共趋化活性。

1,25-Dihydroxycholecalciferol inhibits the cochemotactic activity of Gc (vitamin D binding protein).

作者信息

Petrini M, Azzarà A, Carulli G, Grassi B, Ambrogi F, Galbraith R M

机构信息

Servizio di Ematologia, Università di Pisa, Italy.

出版信息

J Endocrinol Invest. 1991 May;14(5):405-8. doi: 10.1007/BF03349090.

DOI:10.1007/BF03349090
PMID:1875017
Abstract

The identification of Gc (vitamin D binding protein) with the anionic polypeptide cochemotaxin has recently been reported. In this paper we investigate its dose dependent cochemotactic activity and report the inhibition of Gc enhanced chemotaxis by vitamin D3. These results further support the role of immunomodulating hormone played by vitamin D.

摘要

最近有报道称，已确定Gc（维生素D结合蛋白）与阴离子多肽共趋化因子相同。在本文中，我们研究了其剂量依赖性共趋化活性，并报告了维生素D3对Gc增强趋化作用的抑制。这些结果进一步支持了维生素D发挥免疫调节激素的作用。

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1
1,25-Dihydroxycholecalciferol inhibits the cochemotactic activity of Gc (vitamin D binding protein).1,25-二羟胆钙化醇抑制Gc（维生素D结合蛋白）的共趋化活性。
J Endocrinol Invest. 1991 May;14(5):405-8. doi: 10.1007/BF03349090.
2
Selective inhibition of the C5a chemotactic cofactor function of the vitamin D binding protein by 1,25(OH)2 vitamin D3.1,25-二羟维生素D3对维生素D结合蛋白C5a趋化辅因子功能的选择性抑制作用
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3
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J Clin Invest. 1988 Jul;82(1):360-3. doi: 10.1172/JCI113595.
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Gc-globulin (vitamin D-binding protein) enhances the neutrophil chemotactic activity of C5a and C5a des Arg.Gc球蛋白（维生素D结合蛋白）增强C5a和C5a去精氨酸的中性粒细胞趋化活性。
J Clin Invest. 1988 Jul;82(1):364-9. doi: 10.1172/JCI113596.
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Human prostate cancer cells: inhibition of proliferation by vitamin D analogs.人前列腺癌细胞：维生素D类似物对其增殖的抑制作用
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Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity.Gc蛋白（维生素D结合蛋白）：Gc基因分型与GcMAF前体活性。
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Analysis of regulatory regions in the COL1A1 gene responsible for 1,25-dihydroxyvitamin D3-mediated transcriptional repression in osteoblastic cells.对成骨细胞中负责1,25 - 二羟基维生素D3介导的转录抑制的COL1A1基因调控区域的分析。
J Cell Biochem. 1994 Dec;56(4):490-501. doi: 10.1002/jcb.240560409.
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[Mechanism of immunomodulating effect of vitamin D: possible involvement of lipid peroxidation system].
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Identification of the serum factor required for in vitro activation of macrophages. Role of vitamin D3-binding protein (group specific component, Gc) in lysophospholipid activation of mouse peritoneal macrophages.体外激活巨噬细胞所需血清因子的鉴定。维生素D3结合蛋白（群体特异性成分，Gc）在小鼠腹腔巨噬细胞溶血磷脂激活中的作用。
J Immunol. 1991 Jul 1;147(1):273-80.

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Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice.维生素 D 结合蛋白缺陷小鼠中，C5a 和 CXCL1 诱导的肺泡炎中中性粒细胞向肺的募集受损。
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Cofactor regulation of C5a chemotactic activity in physiological fluids. Requirement for the vitamin D binding protein, thrombospondin-1 and its receptors.

本文引用的文献

1
Vitamin D-binding protein (Gc-globulin) binds actin.维生素D结合蛋白（Gc球蛋白）结合肌动蛋白。
J Biol Chem. 1980 Mar 25;255(6):2270-2.
2
1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells.1α,25-二羟维生素D3抑制正常人外周血单个核细胞的增殖及免疫球蛋白产生。
J Clin Invest. 1984 Aug;74(2):657-61. doi: 10.1172/JCI111465.
3
Linkage between surface immunoglobulin and cytoskeleton of B lymphocytes may involve Gc protein.B淋巴细胞表面免疫球蛋白与细胞骨架之间的联系可能涉及Gc蛋白。
生理液中 C5a 趋化活性的辅助因子调节。维生素 D 结合蛋白、血小板反应蛋白-1 及其受体的需求。
Mol Immunol. 2011 Dec;49(3):495-503. doi: 10.1016/j.molimm.2011.09.024. Epub 2011 Oct 19.
4
Upregulation of vitamin D binding protein (Gc-globulin) binding sites during neutrophil activation from a latent reservoir in azurophil granules.在嗜天青颗粒中潜在储存库的中性粒细胞激活过程中维生素D结合蛋白（Gc球蛋白）结合位点的上调。
Mol Immunol. 2007 Mar;44(9):2370-7. doi: 10.1016/j.molimm.2006.10.011. Epub 2006 Nov 20.
5
Selective inhibition of the C5a chemotactic cofactor function of the vitamin D binding protein by 1,25(OH)2 vitamin D3.1,25-二羟维生素D3对维生素D结合蛋白C5a趋化辅因子功能的选择性抑制作用
Mol Immunol. 2006 Mar;43(8):1109-15. doi: 10.1016/j.molimm.2005.07.023. Epub 2005 Aug 22.
Nature. 1983;306(5938):73-4. doi: 10.1038/306073a0.
4
Brevin and vitamin D binding protein: comparison of the effects of two serum proteins on actin assembly and disassembly.肌动蛋白结合蛋白与维生素D结合蛋白：两种血清蛋白对肌动蛋白组装和解聚作用的比较
Biochemistry. 1984 Jun 19;23(13):3038-47. doi: 10.1021/bi00308a030.
5
1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone.1,25-二羟基维生素D3：一种新型免疫调节激素。
Science. 1984 Jun 29;224(4656):1438-40. doi: 10.1126/science.6427926.
6
Gc (vitamin D binding protein) binds to cytoplasm of all human lymphocytes and is expressed on B-cell membranes.Gc（维生素D结合蛋白）与所有人类淋巴细胞的细胞质结合，并在B细胞膜上表达。
Clin Immunol Immunopathol. 1984 May;31(2):282-95. doi: 10.1016/0090-1229(84)90248-4.
7
1,25-dihydroxyvitamin D3 receptors in human leukocytes.人白细胞中的1,25 - 二羟维生素D3受体
Science. 1983 Sep 16;221(4616):1181-3. doi: 10.1126/science.6310748.
8
Human serum binding protein for vitamin D and its metabolites (DBP): evidence that actin is the DBP binding component in human skeletal muscle.人血清维生素D及其代谢产物结合蛋白（DBP）：肌动蛋白是人骨骼肌中DBP结合成分的证据。
Arch Biochem Biophys. 1982 Feb;213(2):538-44. doi: 10.1016/0003-9861(82)90581-1.
9
Identification of a major endogenous substrate for phospholipid/Ca2+-dependent kinase in pancreatic acini as Gc (vitamin D-binding protein).鉴定胰腺腺泡中磷脂/钙依赖性激酶的一种主要内源性底物为Gc（维生素D结合蛋白）。
FEBS Lett. 1985 Oct 21;191(1):97-101. doi: 10.1016/0014-5793(85)81001-2.
10
Distinct sites on the G-actin molecule bind group-specific component and deoxyribonuclease I.G-肌动蛋白分子上的不同位点可结合群体特异性成分和脱氧核糖核酸酶I。
Biochem J. 1985 Jun 1;228(2):471-7. doi: 10.1042/bj2280471.