Basu Analabha, Tang Hua, Zhu Xiaofeng, Gu C Charles, Hanis Craig, Boerwinkle Eric, Risch Neil
Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Ave., Room 901H HSW, San Francisco, CA 94143, USA.
Hum Genet. 2008 Oct;124(3):207-14. doi: 10.1007/s00439-008-0541-5. Epub 2008 Aug 28.
Migrations to the new world brought together individuals from Europe, Africa and the Americans. Inter-mating between these migrant and indigenous populations led to the subsequent formation of new admixed populations, such as African and Latino Americans. These unprecedented events brought together genomes that had evolved independently on different continents for tens of thousands of years and presented new environmental challenges for the indigenous and migrant populations, as well as their offspring. These circumstances provided novel opportunities for natural selection to occur that could be reflected in deviations at specific locations from the genome-wide ancestry distribution. Here we present an analysis examining European, Native American and African ancestry based on 284 microsatellite markers in a study of Mexican Americans from the Family Blood Pressure Program. We identified two genomic regions where there was a significant decrement in African ancestry (at 2p25.1, p < 10(-8) and 9p24.1, p < 2 x 10(-5)) and one region with a significant increase in European ancestry (at 1p33, p < 2 x 10(-5)). These locations may harbor genes that have been subjected to natural selection after the ancestral mixing giving rise to Mexicans.
向新大陆的移民汇聚了来自欧洲、非洲和美洲的人群。这些移民群体与本土人群之间的通婚导致了新的混合人群的形成，比如非裔美国人和拉丁裔美国人。这些前所未有的事件将在不同大陆独立进化了数万年的基因组汇聚在一起，给本土人群、移民群体及其后代带来了新的环境挑战。这些情况为自然选择提供了新的机会，这可能会反映在全基因组祖先分布的特定位置出现偏差。在此，我们基于家庭血压项目中对墨西哥裔美国人的研究，利用284个微卫星标记对欧洲、美洲原住民和非洲血统进行了分析。我们确定了两个非洲血统显著减少的基因组区域（位于2p25.1，p < 10^(-8)；以及9p24.1，p < 2×10^(-5)）和一个欧洲血统显著增加的区域（位于1p33，p < 2×10^(-5)）。这些位置可能含有在祖先混合形成墨西哥人之后经历了自然选择的基因。
