Aarons L
Pharmacy Department, University of Manchester, United Kingdom.
J Pharmacokinet Biopharm. 1991 Jun;19(3):265-9. doi: 10.1007/BF03036250.
Steady state plasma and synovial fluid flurbiprofen concentrations obtained from 26 rheumatoid arthritis patients receiving 100 mg of flurbiprofen b.i.d. were analyzed using the NONMEM program. Only one synovial fluid sample per patient was available. Population estimates for the plasma parameters, clearance, volume of distribution, and elimination half-life were 1.75 L hr-1, 11.9 L, and 4.8 hr, respectively, and the corresponding interindividual variances in these parameters were 29, 19 and 23%, respectively. The apparent elimination half-life from synovial fluid was 7.1 hr. After accounting for interindividual variability there was a residual variability of approximately 40% in both the plasma and synovial fluid concentrations.
对26名接受每日两次100mg氟比洛芬治疗的类风湿性关节炎患者的稳态血浆和滑液中氟比洛芬浓度，使用NONMEM程序进行了分析。每位患者仅有一份滑液样本。血浆参数清除率、分布容积和消除半衰期的群体估计值分别为1.75L·hr⁻¹、11.9L和4.8小时，这些参数的个体间变异分别为29%、19%和23%。滑液的表观消除半衰期为7.1小时。在考虑个体间变异性后，血浆和滑液浓度中仍存在约40%的残余变异性。
