Spahn H, Thabe K, Mutschler E, Tillmann K, Gikalov I
Eur J Clin Pharmacol. 1987;32(3):303-7. doi: 10.1007/BF00607579.
The concentration-time curves of azapropazone in synovial fluid and tissues have been studied in arthritic patients after an i.v. bolus (600 mg) and under steady-state conditions. Synovial fluid and tissue samples were taken intraoperatively 0.45-60 h after administration. The azapropazone concentrations in synovial fluid, synovial tissue and plasma were correlated. The levels in synovial fluid were usually lower than corresponding plasma levels. Under steady-state conditions azapropazone did not accumulate in synovial tissues.
已对关节炎患者静脉推注（600毫克）后及稳态条件下阿扎丙宗在滑液和组织中的浓度-时间曲线进行了研究。给药后0.45至60小时在手术中采集滑液和组织样本。滑液、滑膜组织和血浆中的阿扎丙宗浓度具有相关性。滑液中的水平通常低于相应的血浆水平。在稳态条件下，阿扎丙宗不会在滑膜组织中蓄积。
