Beal S L, Sheiner L B
Crit Rev Biomed Eng. 1982;8(3):195-222.
This paper will review the methods that have been advanced for the estimation of parameters of models quantifying the population characteristics of the kinetic behavior of endogenous and exogenous substances in individuals of the population. Such methods are used frequently, for example, in pharmacokinetic studies. In certain populations, especially biological ones, considerable kinetic variability between population members is present. The models with which we are concerned describe this variability. Some interindividual kinetic variability may be explainable on the basis of measureable concomitant variables, but much of it may remain unexplainable on such a basis. We give this matter particular attention. The assumptions underlying the models are critically discussed.
本文将回顾那些已被提出的用于估计模型参数的方法，这些模型用于量化人群中个体内源性和外源性物质动力学行为的群体特征。例如，这类方法在药代动力学研究中经常被使用。在某些群体中，尤其是生物群体，群体成员之间存在相当大的动力学变异性。我们所关注的模型描述了这种变异性。一些个体间的动力学变异性可以基于可测量的伴随变量来解释，但基于此，很多变异性可能仍然无法解释。我们特别关注这个问题。对模型所基于的假设进行了批判性讨论。
