Miyamoto Misa, Kodama Chiine, Kinoshita Toru, Yamashita Fumio, Hidaka Shin, Mizukami Katsuyoshi, Kakuma Tatsuyuki, Asada Takashi
Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan.
J Clin Neurosci. 2009 Feb;16(2):270-6. doi: 10.1016/j.jocn.2008.03.007. Epub 2008 Dec 16.
We aimed to estimate the prevalence of mild cognitive impairment (MCI) among elderly non-responders to a community-based survey. We conducted a two-phase, population-based cross-sectional study of community-dwelling individuals aged 65 years or older in Tone, located in central Japan. The first phase of the study consisted of physical and cognitive examinations of individuals who responded to the first recruitment (quick-responders), whereas the second phase included individuals who did not respond in the first phase (delayed-responders). We compared the prevalence of MCI and dementia between delayed-responders and quick-responders. Of the 2,698 potential candidates, 1,888 (1,619 quick-responders, 225 delayed-responders, and 44 nursing home residents) were enrolled (70.0%). The prevalence of MCI was 2.3-fold increased in delayed-responders compared to the quick-responders (OR=2.27, 95% CI: 1.37-3.77, p=0.002, aged< or =74). In order to develop a method for the early detection of dementia, we must pay more attention to delayed-or non-responders.
我们旨在估计在一项基于社区的调查中未做出回应的老年人中轻度认知障碍(MCI)的患病率。我们对日本中部利根地区65岁及以上居住在社区的个体进行了一项两阶段、基于人群的横断面研究。研究的第一阶段包括对首次招募时做出回应的个体(快速回应者)进行身体和认知检查,而第二阶段包括在第一阶段未做出回应的个体(延迟回应者)。我们比较了延迟回应者和快速回应者之间MCI和痴呆症的患病率。在2698名潜在候选人中,有1888人(1619名快速回应者、225名延迟回应者和44名养老院居民)被纳入研究(70.0%)。与快速回应者相比,延迟回应者中MCI的患病率增加了2.3倍(OR=2.27,95%CI:1.37 - 3.77,p = 0.002,年龄≤74岁)。为了开发一种早期检测痴呆症的方法,我们必须更加关注延迟回应者或无回应者。