艾滋病病毒疫苗研究简史：要重新回到绘图板吗？

A brief history of HIV vaccine research: stepping back to the drawing board?

作者信息

Miedema Frank

机构信息

University Medical Center Utrecht, Utrecht, The Netherlands.

出版信息

AIDS. 2008 Sep 12;22(14):1699-703. doi: 10.1097/QAD.0b013e3283021a61.

DOI:10.1097/QAD.0b013e3283021a61

PMID:18753857

Abstract

In September 2007, it was announced that the most promising HIV vaccine trial had to be stopped because it had failed to show the protection that was hoped for. Here, the history of HIV vaccine development from the discovery of HIV-1 in 1983 until 2008, the underlying ideas on protective immunity to HIV and potential avenues for vaccine research are discussed.

摘要

2007年9月，有消息称，最具前景的艾滋病疫苗试验不得不停止，因为它未能展现出预期的保护效果。本文将探讨从1983年发现HIV-1到2008年艾滋病疫苗的研发历程、针对HIV保护性免疫的基本理念以及疫苗研究的潜在途径。