Méndez-Sánchez Nahum, Villa Antonio R, Vázquez-Elizondo Genaro, Ponciano-Rodríguez Guadalupe, Uribe Misael
Liver Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico.
Ann Hepatol. 2008 Jul-Sep;7(3):226-9.
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, with an estimated incidence of half a million new cases per year around the world. Furthermore, HCC is the third greatest cause of cancer-related death in the world, and most of these deaths are registered in developing countries. Recently it has been suggested that Hispanics in the United States have high rates of HCC, but no information regarding this is available in Mexico. The aim of this study was to investigate recent trends (2000-2006) in HCC mortality rates in Mexico.
Data on national mortality (death certificates) reported for the years 2000-2006 by the Health Ministry of Mexico were analyzed (www.salud.gob.mx). HCC as a cause of death was analyzed. Mortality rates were calculated for all population ages. Causes of death related to HCC were selected in accordance with the International Classification of Diseases, 10th Revision, Liver Cancer (C22.0, C22.7, C22.9).
We found that age-adjusted mortality rates were remarkably higher in men than in women in the period 2000-2006. In addition, we found an increase in the general mortality rates of HCC from 4.1 per 100,000 in 2000 to 4.7 per 100,000 in 2006.
The results of this study suggest an increase in the mortality rate for HCC in the period 2000-2006. HCC will become a significant cause of morbidity and mortality in the near future.
肝细胞癌（HCC）是最常见的原发性肝癌，全球每年估计有五十万新发病例。此外，HCC是全球第三大致癌相关死亡原因，且大多数死亡病例发生在发展中国家。最近有研究表明，美国的西班牙裔人群HCC发病率较高，但墨西哥尚无相关信息。本研究旨在调查墨西哥肝细胞癌死亡率的近期趋势（2000 - 2006年）。
分析了墨西哥卫生部报告的2000 - 2006年全国死亡率数据（www.salud.gob.mx）。对作为死亡原因的HCC进行了分析。计算了所有年龄段人群的死亡率。与HCC相关的死亡原因按照国际疾病分类第十版肝癌（C22.0、C22.7、C22.9）进行选择。
我们发现，2000 - 2006年期间，年龄调整后的死亡率男性显著高于女性。此外，我们发现HCC的总体死亡率从2000年的每10万人4.1例增加到了2006年的每10万人4.7例。
本研究结果表明，2000 - 2006年期间HCC死亡率有所上升。在不久的将来，HCC将成为发病和死亡的重要原因。
